DETERMINANTS OF CORONARY COLLATERAL DEVELOPMENT

本申请中描述的研究的具体目标是： (1)测定未成熟冠脉的功能能力 (无肌层的薄壁血管)冠状动脉术后即刻 动脉闭塞和闭塞的前几周。 (2)测定成熟冠状动脉侧支的功能容量 (已形成肌壁并具有自我调节功能的血管 在冠状动脉闭塞后的几个月内)。 (三)确定发展从不成熟到成熟所需的时间 冠脉闭塞后冠脉侧支血管的形态。 (4)定量观察冠脉侧支的形态变化。 未成熟和成熟的维管束。 (5)确定各种干预措施对冠脉病变的影响 侧支循环、局部心肌功能和冠状动脉侧支循环 血管形态测量。 (六)确定在发展过程中是否存在活跃的成长过程 冠状动脉侧支血管的三代胸腺嘧啶核苷测定。 冠状动脉的功能和结构意义的研究 侧支循环旨在检验三个假说，即(1) 当冠状动脉侧支自身重塑成小动脉或小动脉时 肌肉动脉，它们在功能上变得重要；(2)有 冠状动脉闭塞后床上存在危险的活功能组织；以及(3) 冠状动脉侧支的生长速度，冠状动脉的机械功能 处于危险状态的床和处于危险状态的床中可存活的功能组织的数量 在冠状动脉闭塞后，运动和药物会增加冠脉闭塞。

The specific aims of the research described in this application are: (1) To determine the functional capacity of immature coronary collaterals (thinwalled vessels without muscular coats) immediately after coronary artery occlusion and during the first few weeks of occlusion. (2) To determine the functional capacity of mature coronary collaterals (vessels that have developed a muscular wall and have autoregulatory capacity) during the months after coronary artery occlusion. (3) To determine the time necessary for development from immature to mature forms of coronary collateral vessels after the onset of coronary occlusion. (4) To quantitate the morphologic changes occurring in coronary collateral vessels in both immature and mature forms. (5) To determine the effects of various interventions on coronary collateral flow, regional myocardial function and coronary collateral vessel morphometry. (6) To determine if there is an active growth process in the development of coronary collateral vessels using triated thymidine. These studies of the functional and structural significance of the coronary collateral circulation are designed to examine three hypotheses, i.e., (1) when coronary collaterals remodel themselves into arterioles or small muscular arteries, they becomes functionally significant; (2) there is viable functional tissue in bed at risk after coronary occlusion; and (3) the rate of growth of coronary collaterals, the mechanical function of the bed at risk and the amount of viable functional tissue in the bed at risk after coronary occlusion are augmented by exercise and drugs.