SERUM CHOLESTEROL, BLOOD PRESSURE, AND MORTALITY

该数据涉及11，320名最初年龄在40-59岁之间的男性， 心血管疾病，建议分析之间的相互关系 某些进入特征以及这些特征之间的关系， 冠状动脉疾病癌症和各种原因的死亡 男人们组成15个队列， 芬兰、希腊、意大利、日本、荷兰、美国和 南斯拉夫13岁以上男性占90%以上 在铁路的特定区域和特定职业和位置， 美国和意大利的工业。 在15年里， 男性死亡; 603人死于癌症，561人死于冠心病， 不同群体和区域之间差异显著。 注意的特征是相对体重（体重指数）， “框架”由高度和双峰巅和双峰巅直径表示， 肥胖程度由皮褶厚度、血压、血清胆固醇 吸烟习惯。 这些特征之间的相互关系， 它们与死亡率之间的关系将按队列进行检查， cohorts的组。 重点将放在没有假设的方法上 关系的形式和变量的分布。 据信，分析将发现曲线以及线性 关系，并指出关系在多大程度上相似， 生活方式和其他特征不同的人群。 结果 应该有助于考虑可能的预防方案。 它 人们认识到，在有限的时间内可能无法充分实现这些目标， 建议，但可以承诺取得重要进展，因为数据在 以可访问的形式提交，分析需求得到理解， 申请人已对该材料进行的试验表明了所使用的方法 和追踪方向

With data on 11,320 men initially aged 40-59 and without evidence of cardiovascular disease, it is proposed to analyze interrelationships among certain entry characteristics and between those characteristics and coronary, cancer, and all-causes deaths. The men form 15 cohorts in Finland, Greece, Italy, Japan, the Netherlands, the United States, and Yugoslavia comprising over 90% of all men of the age of 13 geographically defined areas and in specified occupations and locations in the railroad industry in the United States and in Italy. In 15 years, 2,136 of those men died; 603 from cancer, 561 from coronary heart disease, and mortality varied markedly among cohorts and regions. Characteristics for attention are relative weight (body mass index), "frame" indicated by height and bi-acromial and bi-cristal diameters, fatness indicated by skinfold thickness, blood pressure, serum cholesterol, and smoking habit. Inter-relationships among these characteristics and relationships between them and mortality will be examined by cohorts and groups of cohorts. Emphasis will be put on methods without assumptions about the form of the relations and the distributions of the variables. It is believed the analyses will find curvilinear as well as linear relationships and indicate the extent to which relationships are similar in populations differing in mode of life and other features. The results should be useful in the consideration of possible preventive programs. It is realized that the goals may not be fully attained in the limited period proposed, but important progress can be promised because the data are at hand in accessible form, the analytical needs are understood, and much work already done on this material by the applicant indicates methods to be used and directions to pursue.