MYOCARDIAL ACID-BASE CHANGES DURING CPR

描述（改编自申请人摘要）：复苏 研究主要集中在心脏病的初始阶段， 复苏和选择，通过可行的节奏和自发 可以恢复循环。 然而，定义不太明确的是， 心脏骤停后心肌的代谢和机械命运 被逆转了。 目前的建议解决了这两个阶段的心脏 复苏，特别关注药物干预。目标 是定义的理由，适应症，时间和顺序 血管加压药/正性肌力药和缓冲剂治疗，并了解其潜力 交互. 一系列的实验将在一个 建立了猪心脏骤停模型，其中复苏将 尝试传统的闭胸方法。 心肌血流入 结合冠状动脉动静脉O2、CO2和乳酸梯度， 直接测量心肌PO 2、（H+）、PC 02可作为 改变心肌代谢，尤其是缺血。心肌PC 02 也可以作为心肌梗死严重程度和预后的标志。 缺血 左心室压力-容积测量，使用 电导法，将提供心肌收缩力的指标， 放松和顺从。

DESCRIPTION (adapted from the applicant's abstract): Resuscitation research has focused primarily on the initial stage of cardiac resuscitation and options by which a viable rhythm and spontaneous circulation could be restored. Less well defined, however, is the metabolic and mechanical fate of the myocardium after cardiac arrest has been reversed. The current proposal addresses these two stages of cardiac resuscitation with special focus on pharmacological interventions. The goal is to define the rationale, indication, timing and sequencing of vasopressor/inotropic and buffer therapy and to understand their potential interactions. A sequence of experiments would be performed on an established porcine model of cardiac arrest in which resuscitation would be attempted by conventional closed-chest methods. Myocardial blood blow in conjunction with coronary arteriovenous 02, C02, and lactate gradients and direct measurement of myocardial PO2, (H+), PC02 would serve as measures of altered myocardial metabolism and especially of ischemia. Myocardial PC02 would also serve as a marker of the severity and prognosis of myocardial ischemia. Left ventricular pressure-volume measurements, utilizing the conductance method, would provide indices of myocardial contractility, relaxation and compliance.