Application of boronate ester-appended scaffolds in drug-discovery

该项目旨在改善碳水化合物的合成。糖化学是有机合成与生物学相结合的一门日益重要的化学科学。该项目将开发将硼酸酯残基结合到单糖的选定碳上并转化它们以获得迄今为止无法获得的药物发现支架的方法。该策略可用于其他生物重要化合物的受控组装，包括氮杂环、氧杂环和肌醇。用于碳水化合物的受控多样化的方法预计将广泛适用于从糖生物学到医学的科学努力。成功的执行将提供新的药物发现工具，并确保澳大利亚在这一迅速发展的学科中保持竞争地位。

This project aims to improve carbohydrate synthesis. Glycochemistry is an increasingly important chemical science that combines organic synthesis with biology. This project will develop methodologies that incorporate boronate ester residues onto selected carbons of monosaccharides and transform them to obtain hitherto inaccessible scaffolds for drug discovery. This strategy can be used in the controlled assembly of other biologically important compounds, including azacycles, oxacycles and inositols. The methods for the controlled diversification of carbohydrates are expected to be broadly applicable to scientific endeavours ranging from glycobiology to medicine. Successful execution will provide new drug-discovery tools and ensure Australia secures a competitive position in this rapidly expanding discipline.