New Multiple Bond-Forming Strategies for Organic Synthesis

现代合成化学最重要的目标之一是方便地构建在生物环境中有相关应用的分子。虽然历史上大多数药物化合物都来自天然来源，但现代药物通常是通过化学合成来制备的。生物活性分子的从头构建有几个优点，包括：1)产生可能表现出更好的生理性质的结构相关类似物的前景；2)制备更大量材料的能力；3)发现新的化学合成方法的潜力，这些方法的应用超出了最初观察到的背景。无论化合物的最终用途是作为治疗剂、用于阐明生物途径的探针还是对农业有益的材料，制备结构的方法必须是有效的。对更环保、更节省原子的过程的需求，在时间、所需资源和每次反应产生的废物方面最大限度地提高效率，构成了研究新的合成方法的主要推动力。这一提议试图为有机分子的构建开发一种新的范例。拟议的反应性将通过在一次操作中形成多个键来高效地生产生物相关产品。此外，将实现这一转化的关键试剂以催化方式使用，使单个试剂分子能够产生许多分子的产品，从而将反应过程中产生的废物降至最低。为了说明创新方法对合成界的力量，一旦建立了反应性参数，将应用于合成结构复杂、生物相关的分子。所述研究也有望在相对未被探索的有机金属化学领域产生大量新知识。因此，存在着巨大的科学发现机会。这些信息可能会影响学术界和工业部门制造分子的方式。

Among the most important goals of modern synthetic chemistry is the facile construction of molecules that have relevant application in biological settings. Although historically most medicinal compounds have come from natural sources, contemporary drugs are commonly prepared by chemical synthesis. Several advantages result from the de novo construction of biologically active molecules including: 1) the prospective of generating structurally related analogues that may exhibit improved physiological properties; 2) the ability to prepare greater quantities of material; 3) the potential for discovering new methods for chemical synthesis that have application beyond the context in which they were first observed.Whether the end use of the compound is as a therapeutic agent, probe for elucidating biological pathways, or agriculturally beneficial material, the method for preparing the structure must be efficient. The demand for greener more atom-economical processes that maximize efficiency in terms of time, resources required, and waste generated per reaction constitutes a major driving force behind the investigation of new synthetic methods.This proposal seeks to develop a new paradigm for the construction of organic molecules. The proposed reactivity will produce biologically relevant products in an efficient manner by forming multiple bonds in a single operation. In addition, the key reagent that will effect this transformation is used in a catalytic fashion, such that a single molecule of reagent is capable of generating many molecules of the product, thereby minimising the waste generated during the course of the reaction. In order to illustrate the power of the innovative method to the synthetic community, upon establishing reactivity parameters, application to the synthesis of structurally complex, biologically relevant molecules will be undertaken.The research described is also expected to generate substantial new knowledge in a relatively unexplored area of organometallic chemistry. As such, there is vast opportunity for scientific discovery. This information will likely impact the way molecules are made in both the academic and industrial sectors.