CELLULAR IMMUNITY IN DEPRESSIVE ILLNESS

最近有证据表明，中央银行与 神经系统和免疫系统。压力过大的动物表演 几个免疫参数的损害，更有可能 而不是控制动物在接种疫苗时患上癌症 致癌病毒。类似的主机防守错位 机制也被观察到通过注射 下丘脑前部的糖皮质激素和损害。 这些发现的临床意义尚未得到证实。 经过充分调查。流行病学研究表明， 紧张性生活事件后发病率的增加，如 丧亲之痛，并暗示抑郁、 过敏和某些形式的癌症。一些研究表明， 显示出以下不同免疫参数的损害 心理社会压力。关于这一点的研究很少。 抑郁症患者的免疫状态。这个问题是 尤其令人感兴趣的是最近在抑郁症方面的发现 下丘脑-垂体-肾上腺功能紊乱5例 轴系活动常导致分泌量过多 皮质醇，一种免疫抑制激素。 我们最近提出了一种假设，即抑郁症可能 伴随着免疫反应受损，可能 解释报告的感染、过敏发生率增加的原因 以及抑郁症患者的癌症。来自我们自己的初步数据 实验室显示体外淋巴细胞有丝分裂抑制 抑郁症患者与正常对照组的活动度比较。这 提案寻求进一步探索免疫的可能性 抑郁症患者的功能障碍 包括过敏皮肤在内的一系列免疫学测试 用单克隆法检测、分析淋巴细胞表面标志 抗体，评估体外淋巴母细胞转化 以及自然杀伤细胞活性的检测。抑郁症患者 将在抑郁症的急性期和 在康复之后。免疫功能的比较也将是 在临床和神经内分泌亚型之间 抑郁症。抑郁症患者也将被比作 精神分裂症对照，压力很大，但不是这样 精神状态良好的对照组和正常对照组。

There has recently been evidence of links between the central nervous system and the immune system. Stressed animals show impairment in several immune parameters and are more likely than control animals to develop cancer when inoculated with an oncogenic virus. Similar derangements in host-defense mechanisms have also been observed with injections of glucocorticoids and lesions in the anterior hypothalamus. The clinical implications of these findings have not been adequately investigated. Epidemiological studies show an increase in morbidity rates following stressful life events such as bereavement and suggest an association between depression, allergy and certain forms of cancer. A number of studies have shown an impairment of different immune parameters following psychosocial stress. Very little research has been done on the immune status of patients with depressive illness. This issue is particularly interesting in view of recent findings in depressed patients of a disturbance in the hypothalamic-pituitary-adrenal axis activity often resulting in the secretion of excessive amount of cortisol, an immunosuppressive hormone. We have recently formulated the hypothesis that depression may be accompanied by an impairment of immune responses that could explain the reported increase in the incidence of infection, allergy and cancer in depressed patients. Preliminary data from our own laboratory indicate a suppression of in vitro lymphocyte mitogenic activity in depressed patients compared to normal controls. This proposal seeks to further explore the possibility of immune dysfunction in patients with depressive illness by giving them a battery of immunological tests, including hypersensitivity skin testing, lymphocyte surface marker analysis with monoclonal antibodies, assessment of in vitro lymphoblast transformations and an assay of natural killer cell activity. Depressed patients will be studied both during the acute phase of depression and following recovery. Comparisons of immune function will also be made between clinical as well as neuroendocrine subtypes of depression. Depressed patients will also be compared to schizophrenic controls, highly stressed but otherwise psychiatrically-well controls and normal controls.