FAMILY-CHILD STUDY OF AFFECTIVE AND ANXIETY DISORDERS

检查生物学和行为之间的相互作用 精神疾病的传播，比较将在 在母亲有一个主要子女的家庭中， 诊断为严重情感障碍，双相情感障碍， 强迫症或者没有精神疾病拟定研究 将决定（1）情感，双相， 强迫症和无病母亲的行为不同，（2）如果 患有情感障碍、躁郁症或强迫症的母亲 对待孩子的方式与没有这些的母亲不同 （3）如果这些母亲的差异可能与 后代行为的差异;（4）如果母亲的特征， 诊断、疾病严重程度、症状维度或人口统计学 对儿童行为的预测差异;（5）如果传播 跨代是特定的性质，即如果类似的症状是 父母和子女的关系;（6）如果父母的关系是 儿童早期的疾病会影响适应性发展。 为了验证这些假设，1人一组。2-1/2和4岁儿童， 母亲有情感障碍、躁郁症和强迫症， 以及那些没有精神疾病的人将在家里和 实验室的情况。短期趋同纵向研究将 从1岁到2岁半，从2岁半到4岁。在 2-1/2年，180名儿童及其家庭将接受测试：后代 母亲患有严重情感障碍（n-50），双相情感障碍 （n-30），强迫症（n-50），无精神病 干扰（n-50）。其中，120名2岁半的儿童 在1岁时可以看到，在4岁时可以再次看到120。每个 家长将接受一次结构化的精神病学面谈，以确定 DSM-III-R诊断以及症状表达程度。 儿童将单独接受检查，并与父母互动 在认知和掌握任务中的情绪反应和能力。 家庭互动模式将被检查，将家庭环境， 社会支持和生活压力

To examine the interaction between biological and behavioral transmission of psychiatric disorders, comparisons will be made among groups of young children in families where a mother has a primary diagnosis of major affective disorder, bipolar disorder, obsessive-compulsive disorder, or no mental illness. The proposed study will determine (1) if the young offspring of affective, bipolar, obsessive compulsive, and no-illness mothers differ in behavior, (2) if mothers with affective, bipolar, or obsessive compulsive disorders behave differently toward their children than mothers without these disorders; (3) if these maternal differences can be related to differences in offspring behavior; (4) if maternal characteristics such as diagnosis, severity of disorder, symptom dimensions, or demographics are differentially predictive of child behavior; (5) if transmission across generations is specific in nature, i.e. if similar symptoms are apparent in parent and offspring; and (6) if the course of parent illness during the child's early years impacts on adaptive development. To test these hypotheses groups of 1. 2-1/2, and 4 Year old children who have mothers with affective, bipolar, and obsessive compulsive disorder, as well as those with no mental illness will be examined at home and in laboratory situations. Short-term convergent longitudinal studies will be completed from I to 2-1/2 years and from 2-1/2 to 4 years of age. At 2-1/2 years, 180 children and their families will be tested: offspring of a mother with major affective disorder (n-50), bipolar disorder (n-30), obsessive compulsive disorder (n-50), and no psychiatric disturbance (n-50). Of these, 120 of the 2-1/2 year old will have been seen at 1 year of age, and 120 will be seen again at the age of 4. Each parent will be given a structured psychiatric interview to determine DSM-III-R diagnosis as well as the degree of symptom expression. Children will be examined alone and in interaction with their parents for emotional responses and competence in cognitive and mastery tasks. Family interaction patterns will be examined as will home environments, social supports, and life stresses.