CALORIC DENSITY AND AD LIB FEEDING FOR PRETERM INFANTS

喂养方式可能会影响具有重大临床意义的转归 新生儿重症监护病房中的早产儿。这些结果包括 饮食摄入量和体细胞生长。尽管这一理论的科学基础 早产儿的营养已经确立，但对此知之甚少 新乳头喂养对早产儿喂养的影响 这些喂养结果。这项拟议研究的目的是研究 饲喂实践的两个组成部分--调节(即， 处方与随意喂养)和饮食类型(即20卡路里/盎司 配方奶与24卡路里/盎司配方奶)对早产儿膳食摄入量的影响 他们成熟，身体稳定，可以完全哺乳。 建议研究将使用2×2的随机实验设计 将婴儿分配给临时喂养或规定的喂养方式 并且，在饲养实践中，要达到20或24卡路里/盎司的配方。在… 至少18名婴儿将被随机分配到这四项研究中的每一项 组。所有出生在35周以下的婴儿都住进了NICU 体重与胎龄相适应的妊娠，以及谁是 纯奶瓶喂养将符合这项研究的条件。学习的婴儿必须 没有先天或身体上的问题干扰营养 状态。婴儿可能已从呼吸窘迫综合征中康复 (RDS)或有轻度支气管肺发育不良(BPD)。婴儿期 将被统计控制的特征是：(1)肺 健康状况；以及(2)怀孕后年龄和足月第二天 喂乳头。婴儿的24小时饮食摄入量和每日体重将 作为下列措施的基础：(1)#年的体积，单位为毫升/公斤/天 摄入量；(2)卡路里/公斤/天的摄入量；(3)蛋白质/公斤/天的摄入量。 将使用两个变量来评估体细胞生长：(1)克体重 增重/天除以7天研究期内的平均体重；以及(2) 臂中部肌围增长mm/天。研究假设将是 与Manova进行了五项依赖措施的测试。两人之间的相互作用 两个喂养实践因素(喂养方式和卡路里密度)将 检查过了。

Feeding practice may influence outcomes of major clinical significance for preterm infants in neonatal intensive care units. These outcomes include dietary intake and somatic growth. Although the scientific basis of the nutrition for preterm infants is well established, little is known about how feeding practice for the newly nipple-feeding preterm infant influences these feeding outcomes. The objective of the proposed study is to examine the effect of two components of feeding practice--regulation (i.e., prescribed vs. ad libitum feeding) and dietary type (i.e., 20-calorie/ounce formula vs. 24-calorie/ounce formula) on dietary intake of preterm infants who are mature and medically stable enough to be completely nipple fed. The propose study will use a 2 X 2 experimental design with random assignment of infants to either ad libitum or prescribed feeding practice and, within the feeding practice, to 20- or 24-calorie/ounce formula. At least 18 infants will be randomly assigned to each of the four study groups. All infants admitted to the NICU born at less than 35 weeks gestation with weight that is appropriate for gestational age and who are exclusively bottle fed will be eligible for this study. Study infants must not have congenital or medical problems interfering with nutritional status. Infants may have recovered from Respiratory Distress Syndrome (RDS) or have mild Bronchopulmonary Dysplasia (BPD). Infant characteristics that will be controlled statistically are: (1) pulmonary health status; and (2) postconceptional age and on the second day of full nipple feeding. The infant's 24-hour dietary intake and daily weight will be the basis for the following measures: (1) volume in cc/kg/day of intake; (2) kcalories/kg/day of intake; and (3) g protein/kg/day of intake. Two variables will be used to assess somatic growth: (1) grams weight gain/day divided by the mean weight for the 7-day study period; and (2) mm/day growth in mid-arm muscle circumference. Study hypotheses will be tested with MANOVA with five dependent measures. The interaction of the two feeding practice factors (feeding regimen and caloric density) will be examined.