NARCOLEPSY: CLINICAL RESEARCH TO IMPROVE TREATMENT

这项拟议的研究旨在评估匹莫林的疗效， 哌醋甲酯和普罗替林治疗发作性睡病。 一 将采用双盲、多种药物、多剂量水平设计。 保持清醒的能力以及认知和运动任务的表现将 在未用药和治疗期间对发作性睡病患者进行测量 三种不同剂量的药物 正常对照 将以类似于用于 发作性睡病患者 控制组的受试者会被告知， 服用兴奋剂，但实际上会在整个过程中给予安慰剂 书房 因此，安慰剂和重复测量的影响将是 评估。 该项目将实现以下目标：1）建立一个 客观的方法来评估病人的变化。 2)确定 感觉嗜睡和保持清醒的能力之间的关系， 表演。 3)确定主观警觉性、 保持清醒，表现以剂量相关的方式变化。 4)法测定 三种药物的相对有效性通常用于治疗 嗜睡症

The proposed research is designed to evaluate the efficacy of pemoline, methylphenidate and protriptyline in the treatment of narcolepsy. A double-blind, multiple drug, multiple dose level design will be employed. Ability to remain awake and performance on cognitive and motor tasks will be measured in narcoleptic patients while unmedicated and while treatment with one of the drugs at three different dose levels. A normal control group will be studied four times in manner similar to that used for narcoleptic patients. Control subjects will be told that they are going to be medicated with stimulants, but will actually be given placebo throughout the study. Thus the effects of placebo and repeated measurement will be assessed. The project will accomplish the following: 1) Establish an objective method for assessing a patient's alterness. 2) Determine the relation between perceived somnolence and ability to stay awake and perform. 3) Determine if improvement in subjective alertness, ability to stay awake and performance change in a dose-related manner. 4) Determin the relative effectiveness of three drugs typically used to treat narcolepsy.