CEREBRAL BLOOD FLOW AND CAPILLARY RECRUITMENT

这项建议的主旨是确定毛细管的范围。 招募控制脑血流量(CBF)。重点将是 处于控制系统的功能状态，因为它在 大脑皮层的微血管。无论是时间上还是空间上 毛细招募控制系统的质量将通过以下方式进行研究 改变影响脑血流量的生理变量。两者之间的联系 氧循环、CBF微观非均质性或CBF柱状分布， 大脑皮层的血管结构都支持 基于毛细管补充模型的CBF控制系统。目的 这项建议的目的是研究和定义这个假想的控制系统 新开发的实验技术。CBF的快速快照 目前的放射自显影技术和 介绍一种可同时使用的血管着色剂 CBF研究将阐明这一功能和机制 假想的控制系统。CBF将在两种不同的情况下测量 在同一动物中使用双放射性核素放射自显影的间隔时间。 脑血容量将结合脑血流量使用 双标记放射自显影技术。生理变量 已知会影响CBF(PaCO2、PaO2和平均动脉压) 更改以定义CBF的柱状结构的限制和 这一结构与毛细血管募集的关系。功能障碍 这一假想的控制系统的研究将在缺血、缺氧 以及从完全缺血中恢复。 这项研究主要集中在机械和功能方面。 CBF控制室。它的含义和对病理学的应用也将是 地址。

The major thrust of this proposal is to determine the extent of capillary recruitment in the control of cerebral blood flow (CBF). The emphasis will be on the function of the control system as it is effected in the microvessels of the cerebral cortex. Both the temporal and spatial qualities of the capillary recruitment control system will be studied by altering physiological variables that affect CBF. The connection between oxygen cycles, CBF microheterogeneity or the columnar distribution of CBF, and the vascular architecture of the cortex all support the concept of a CBF control system based upon the capillary recruitment model. The purpose of this proposal is to study and define this hypothesized control system with newly developed experimental techniques. The quick snapshot of CBF that is available with the current autoradiographic techniques and the introduction of a vascular stain which can be used at the same time as a CBF study will elucidate the functioning and mechanisms of this hypothesized control system. CBF will be measured over two different intervals in the same animal using double radionuclide autoradiography. Cerebral blood volume will be determined in conjunction with CBF using the double label autoradiographic techniques. The physiological variables known to influence CBF (PaCO2, PaO2 and mean arterial blood pressure) will be altered to define the limits of the columnar structure of CBF and the relationship of this structure to capillary recruitment. The dysfunction of this hypothesized control system will be studied in ischemia, hypoxia and recovery from complete ischemia. This investigation is centered on the mechanistic and functional aspects of CBF control. The implication and applications to pathology will also be addressed.