STUDIES OF THE CALCITONIN RECEPTOR

将进行试点研究，为以下方面提供有用的数据： 降钙素受体的结构和生物化学的研究。 的 降钙素受体将使用光亲和性进行放射性标记 降钙素类似物和化学交联剂。 放射性标记 受体将从细胞膜的去污剂提取物中纯化。 的 降钙素受体的单克隆抗体的发展将是 启动。 有了更多关于降钙素受体的基本信息， 以后可能更详细地研究破骨细胞的特征， 功能和分化，更好地定义降钙素的作用， 正常人骨重建，并确定降钙素是否 缺乏可能在骨质疏松症的病理生理学中是重要的。

Pilot studies will be performed which will provide data useful for the study of the structure and biochemistry of the calcitonin receptor. The calcitonin receptor will be radioactively labeled using photoaffinity analogs of calcitonin and chemical crosslinking agents. The radiolabeled receptor will be purified from detergent extracts of cell membranes. The development of monoclonal antibodies to the calcitonin receptor will be initiated. With more basic information about the calcitonin receptor, it will be possible later to investigate in greater detail the features of osteoclast function and differentiation, to define better the role of calcitonin in normal human bone remodeling, and to determine whether calcitonin deficiency may be important in the pathophysiology of osteoporosis.