NEUROBEHAVIORAL OUTCOME OF ECMO NEONATES AT AGE 5

体外膜肺氧合（ECMO）是一种激烈的治疗应用 严重心肺功能衰竭的危重新生儿。 幸存者代表了一个独特的儿童群体， 在引入程序之前，谁有很高的概率 新生儿脑外伤的症状 鉴于病情的严重性 在ECMO插管治疗前， 风险固有的程序，证据证明了显着的 发育中的大脑适应这种侮辱的潜力。 但只有 关于幸存者的研究有限， 程序正在迅速扩展。 短期随访足以 仅限重大障碍。 一项发表的长期研究只包含16个 孩子 我们建议对150名5岁以下的儿童进行随访， 我们目前的队列在新生儿时接受了ECMO治疗。 所有人都有常规 新生儿期的神经影像学。 将性能与对照品进行比较 50名正常健康的5岁儿童。 性别、种族和母性 教育水平将受到控制。 了全面的多学科 将采用标准的、基础广泛的评估方法， 技术，以评估主要障碍，更集中和详细 评估以记录听觉/语言或 视觉/知觉技能，感觉运动完整性，注意力和 行为问题和神经运动功能障碍 其意义 这项研究将评估长期的神经行为发病率， ECMO幸存者中的一个大的队列，因为他们接近学龄。 的 研究结果也将有助于理解大脑的后果， 近足月新生儿的病变。

Extracorporeal membrane oxygenation (ECMO) is a drastic treatment applied to critically ill near term neonates in severe cardiorespiratory failure. The survivors represent a unique population of children who would have died prior to the introduction of the procedure, and who have a high probability of having sustained neonatal brain trauma. Given the severity of illness among ECMO candidates prior to treatment with ECMO cannulation, and the risks inherent in the procedure, the evidence attests to the remarkable potential of the developing brain to adapt to such insult. However, only limited research is available regarding the survivors, and the use of the procedure is rapidly expanding. Short term follow-up is sufficient for major handicap only. The one published longterm study contained only 16 children. We propose a follow-up of 150 children at 5 years of age from our current cohort who were treated with ECMO as neonates. All had routine neuroimaging in the newborn period. Performance will compared to a control group of 50 normal, healthy 5-year old children. Sex, race, and maternal level of education will be controlled. A comprehensive multidisciplinary approach to assessment will be employed, with both standard, broad-based techniques to evaluate major handicap, and more focused and detailed assessments to document performance in areas of auditory/linguistic or visual/perceptual skills, sensory-motor integrity, attentional and behavioral problems, and neuromotor dysfunction. The significance of this research is that it will evaluate the longterm neurobehavioral morbidity among a large cohort of ECMO survivors as they approach school age. The findings will also contribute to understanding the consequences of brain lesions in near term neonates.