THE CHEMISTRY AND BIOLOGY OF THE FGF

成纤维细胞生长因子(成纤维细胞生长因子)至少构成一个家族 结构上相关的多肽。碱性成纤维细胞生长因子和酸性成纤维细胞生长因子 (a成纤维细胞生长因子)是这个家族中最具特征的成员。他们是 强大的细胞增殖、运动、分化和分化调节剂 生死存亡。它们在体内正常生理过程中发挥着重要作用 胚胎发育、血管生成和伤口修复等过程。 此外，碱性成纤维细胞生长因子和碱性成纤维细胞生长因子是强有力的神经营养因子。一个可能的 成纤维细胞生长因子家族在癌症等病理过程中的作用 随着最近的发现，几个癌基因已经成为 鉴定出与bFGFs和aFGFs有40%-50%序列同源性。这些 癌基因包括INT-2、hst、K-FGF5和FGF5。基金会的另一位成员 角质形成细胞生长因子(KGF)家族，一种特异性的有丝分裂原 上皮细胞最近也被描述过。这次会议将 重点介绍成纤维细胞生长因子家族及其细胞的结构和功能 表面受体，以及它们的生物、生理和 活体病理特性。将详细讨论的主题 包括1)成纤维细胞生长因子家族的结构和生物学特性 (碱性成纤维细胞生长因子、a成纤维细胞生长因子、Int-2、hst、K-fqf、FGF5、FGF.6和KGF)，2)生物合成 碱性成纤维细胞生长因子和碱性成纤维细胞生长因子包括培养细胞的生物合成 天然和修饰的重组碱性成纤维细胞生长因子和碱性成纤维细胞生长因子，转录和 成纤维细胞生长因子合成及定位的翻译调控 3)受体和结合蛋白，包括结构 以及成纤维细胞生长因子高亲和力和低亲和力细胞表面受体的功能 肝素样受体；4)成纤维细胞生长因子的分布和功能 在各种组织中，如眼睛、心脏、肌肉、大脑和皮肤以及 成纤维细胞生长因子与基质和基底膜的关系，5)成纤维细胞生长因子的作用 卵母细胞和胚胎发育中的成纤维细胞生长因子家族成员；6)体内 以及成纤维细胞生长因子家族成员可能的临床作用。这些应用程序 包括血管内皮化、溃疡愈合、创伤 修复和神经元存活。最后，fgf中使用的命名法 菲尔德经常让人感到困惑。本次会议将允许与会者 推荐一个合适的命名法。

The fibroblast growth factors (FGF) constitute a family of at least structurally related polypeptides. Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. They are potent modulators of cell proliferation, motility, differentiation and survival. They play an important role in vivo in normal physiological processes such as embryonic development, angiogenesis, and wound repair. In addition, bFGF and aFGF are potent neurotrophic factors. A possible role for the FGF family in pathological processes such as cancer has become evident with the recent discovery that several oncogenes have been identified that have a 40-50% sequence homology to bFGF and aFGF. These oncogenes include int-2, hst, K-fgf and FGF-5. Another member of the FGF family, keratinocyte growth factor (KGF), a specific mitogen for epithelial cells has also been described recently. This meeting will focus on the structure and function of the FGF family and their cell surface receptors, as well as on their biological, physiological and pathological properties in vivo. The topics to be discussed in detail include 1) The structural and biological properties of the FGF family (bFGF, aFGF, int-2, hst, K-fqf, FGF-5, FGF.6 and KGF), 2) Biosynthesis of bFGF and aFGF including biosynthesis by cultured cells, expression of native and altered recombinant bFGF and aFGF, transcriptional and translational regulation of FGF synthesis and localization of bFGF and aFGF in cells, 3) Receptors and binding proteins including the structure and function of FGF high affinity cell surface receptors and low affinity receptors which are heparin-like, 4) The distribution and function of FGF in various tissues such as eye, heart, muscle, brain and skin as well as the association of FGF with matrix and basement membrane, 5) The role of FGF family members in oocyte and embryonic development, and 6) in vivo and possible clinical roles for FGF family members. These applications include reendothelialization of blood vessels, ulcer healing, wound repair, and neuronal survival. Finally, the nomenclature used in the FGF field has often been confusing. This meeting will allow the participants to recommend a suitable nomenclature.