THYROID STATE AND TRICYCLIC ANTIDEPRESSANT INTERACTIONS

动物研究表明，三环类抗抑郁药(TCA)可产生 去甲肾上腺素和/或5-羟色胺摄取的初始阻断和随后 突触前和突触后神经元的一个或多个群体的变化 感受器。然而，对于这些不同的人中的哪一个存在争议 影响是/主要负责的抗抑郁作用的 毒品。甲状腺状态也被证明影响中枢的状态。 神经元受体，尽管它对摄取机制的影响，如果有的话，有 没有得到广泛的研究。 TCA和甲状腺效应的交错作用在临床上是例证。 已有研究表明，甲状腺激素L-三碘苏氨酸(T3) 加速三氯乙酸在女性体内的抗抑郁作用，并将大约 三分之二的TCA男女都“失败”到“成功”。另一方面 另一方面，甲状腺功能减退症阻止了对这些药物的良好反应。vt.给出 根据这些临床观察，我们有理由认为这些TCA 由T3加速或增强的效果，或延迟或减弱的效果 甲状腺功能减退症可能是这些药物的重要治疗作用 毒品。这项提案中研究的一个总体目标是确定 效果。 TCA-甲状腺交错的重点是肾上腺素能 系统；然而，某些肾上腺素能变化(例如，β受体)需要 完整的5-羟色胺能神经。互动的肾上腺素能和 甲状腺状态和三氯乙酸的5-羟色胺能效应尚未被研究。 广泛地。在这里提出了确定甲状腺状态如何 去甲基米帕明和3-氯丙咪胺对药效的影响 (CLI)对去甲肾上腺素(NE)和5-羟色胺(5-HT)摄取系统的影响 突触后肾上腺素能和5-羟色胺能受体种群。Ne和 5-羟色胺摄取和β-肾上腺素能和5-羟色胺能受体的研究 在大脑皮层和其他选定的甲亢脑区， 甲状腺功能减退和正常大鼠以及这三种甲状腺状态的大鼠 已经用DMI或CLI进行了长期治疗。获得的信息 从这一研究中可能有助于解决当代的一个重要问题 精神药理学。凭借其解决方案，努力设计更有效的 药物可以集中，而我们对其发病机制的认识 情感障碍将会得到加强。

Animal studies have shown that tricyclic antidepressants (TCAs) produce an initial blockade of norepinephrine and/or serotonin uptake and subsequent changes in one or more populations of pre- and post-synaptic neuronal receptors. However, there is controversy over which of these various effects is/are primarily responsible for the antidepressant action of the drugs. Thyroidal state also has been shown to affect the status of central neuronal receptors, though its effects, if any, on uptake mechanisms have not been studied extensively. The interdigitation of TCA and thyroidal effects is exemplified by clinical studies which have shown that the thyroid hormone L-triiodothronine (T3) accelerates the antidepressant action of TCAs in females and converts about two-thirds of TCA "failures" of both sexes to "successes". On the other hand, hypothyroidism prevents a favorable response to these drugs. Given these clinical observations, it is reasonable to assume that those TCA effects which are accelerated or enhanced by T3 or retarded or diminished by hypothyroidism are probably therapeutically important effects of these drugs. A general aim of the research in this proposal is to identify those effects. The focal point of the TCA-thyroidal interdigitation is the adrenergic systems; however, certain adrenergic changes (e.g. Beta-receptors) require intact serotonergic innervations. The interactive adrenergic and serotonergic effects of thyroidal state and TCAs have not been studied extensively. It is proposed here to determine how thyroidal state influences the effects of desmethylimipramine (DMI) and 3-chloroimipramine (CLI) on norepinephrine (NE) and serotonin (5-HT) uptake systems and post-synaptic adrenergic and serotonergic receptor populations. NE and 5-HT uptake and Beta-adrenergic and serotonergic receptors will be studied in cerebral cortex and other selected brain regions of hyperthyroid, hypothyroid and euthyroid rats and rats of these three thyroidal states which have been chronically treated with DMI or CLI. Information gained from this research may help to solve an important problem in contemporary psychopharmacology. With its solution, efforts to design more effective drugs can be focused, and our understanding of the pathogenesis of affective disorders will be enhanced.