RESEARCH CONFERENCE--METALLOPROTEINASES

这项建议是为了支持一个国际研究会议 金属蛋白酶及其在细胞外基质降解中的作用 健康和疾病。这次会议是独特的和及时的，因为最近 研究进展表明，基质金属蛋白酶构成一种 在基因和功能上截然不同但结构上同源的家族 在生物降解中起重要作用的酶 细胞外基质。到目前为止，由一个家族编码的五种酶 高度保守的基因已被确定：成纤维细胞IV型 胶原酶、PMN型胶原酶、基质分解酶、MR 72,000明胶酶/型 IV胶原酶和MR 95000明胶酶。会议将总结新的 以及关于(1)结构和催化性能的现有数据；(2)调节 在基因表达、酶激活、 以及通过天然和合成的抑制剂失活；以及(3)在 细胞外基质的生物降解。会议将提供 对于信息和想法的讨论，达到不能通过 传统的通信手段，如出版和更正式的 科学会议。我们建议将来自世界各地的顶尖科学家 美国和国外参加为期4天半的会议，以评估目前的情况 并讨论今后的研究途径。总数为55至60人 特邀演讲者和主持人，每个人都是各自领域的专家，将是 被要求及时提供关于指定主题的概述和新数据 他们的专业领域。演讲者还将被要求提交一份 手稿，这些将构成出版的基础 会议纪要。海报会议计划开放给 那些希望提供新数据的人。

This proposal is for support of an international research conference on metalloproteinases and their role in extracellular matrix degradation in health and disease. The conference is unique and timely because of recent advances which have shown that matrix metalloproteinases constitute a family of genetically and functionally distinct but structurally homologous enzymes which play an important role in the biologic degradation of extracellular matrices. So far, five enzymes encoded for by a family of highly conserved genes have been identified: fibroblast-type IV collagenase, PMN-type collagenase, stromelysin, Mr 72,000 gelatinase/type IV collagenase, and Mr 95,000 gelatinase. The conference will summarize new and existing data on (1) structure and catalytic properties; (2) regulation of catalytic activity at the levels of gene expression, enzyme activation, and inactivation by natural and synthetic inhibitors; and (3) role in biologic degradation of extracellular matrices. The conference will provide for discussion of information and ideas to an extent not achievable by conventional means of communication, such as publication and more formal scientific meetings. We propose to bring together leading scientists from the U.S. and abroad for a 4 1/2 day conference to evaluate current knowledge and to discuss future avenues of research. A total of 55-60 invited speakers and moderators, each an expert in their field, will be asked to present a timely overview and new data on an assigned topic in their area of expertise. Speakers will also be requested to submit a written manuscript, and these will form the basis for publication of the proceedings of the conference. Poster sessions are planned to be open to those who wish to present new data.