MYELINATION AND DYSMYELINATION

由纽约科学院主办的一次会议 计划召集研究细胞和 髓鞘形成的分子方面。会议的主要焦点将是 髓鞘突变体，因为他们提供了对正常 髓鞘形成的发育过程。在过去的五年里， 主要髓鞘蛋白的基因已经被克隆和测序， 几个髓鞘突变体的遗传基础已经确定。现代 蜂窝技术帮助确定了事件的顺序 导致正常和/或异常的髓鞘形成。现在可以追踪到 从已识别的遗传缺陷到其在细胞中的表达的途径 神经系统。这次会议的目的是将 从关于髓鞘形成的分子和细胞研究中获得的信息 形成一个连贯的模型，以找出我们对此理解上的差距 过程和规划未来的研究方向。 髓鞘生成。上一次专门研究髓鞘形成的会议举行了 八年前，由于这一领域的爆炸性增长，现在是 召开这样一次多学科会议恰逢其时。

A conference under the auspices of the New York Academy of Sciences has been planned to bring together investigators studying the cellular and molecular aspects of myelination. The major focus of the meeting will be the myelin mutants since they have provided new insights into the normal developmental process of myelin formation. Within the last five years, the genes for the major myelin proteins have been cloned and sequenced and the genetic basis for several of the myelin mutants has been identified. Modern cellular technologies have helped to identify the sequence of events leading to normal and/or abnormal myelination. It is now possible to trace the pathway from an identified genetic defect to its cellular expression in the nervous system. The intent of this conference is to integrate the information obtained from molecular and cellular studies about myelination into a coherent model, to identify the gaps in our understanding of this process and to plot future directions of research in the are a of myelinogenesis. The last conference devoted to myelinogenesis was held eight years ago and because of the explosive growth in this area, it is now timely to hold such a multidisciplinary meeting.