EXPERIMENTAL & THEORETICAL ANALYSIS: METABOLIC PROCESS

虽然许多“分子生物学家”可能认为“代谢” 监管”作为一个解决的问题，该领域还远未死亡， 事实似乎正在进入一个新的令人兴奋的阶段。 的 科学已经从一个描述性的科学发展成为一个能够 将生物化学关系和机制整合到动态 术语-接近活细胞的复杂性。 动力学 已经建立了具有预测价值的模型： 最终测试其实用性和普遍有效性。 在 过去，生物化学的进展主要是在 通过分离和深入分析单个细胞 件. 未来的进展很可能取决于 这些丰富的信息可以在多大程度上用于 动态模型，其模拟完整细胞中的代谢， 有机体 只有当还原论和整体论 我们是否真的开始理解 体内代谢 尽管动态分析的基本重要性， 代谢过程，该领域今天是分散和混乱的， 大多数生物化学家的想法。 太多的武断和无用 模型填补了文献。 如果有足够的假设， 代谢系统可以建模，但不一定反映 体内代谢 实验的体积越大， 模型与之一致的数据， 它越有可能描述现实 并找到了一个独特的解决方案。 其主要目的是 会议是建立基本规则的建设和 使用各种代谢模型。 拟议的计划将包括专题讨论会和海报 sessions. 请拨经费用于40名应邀参加会议的人员的旅费 来自国际研究的演讲者和召集人 社区来解决代谢建模的各个方面， 以及20名左右的年轻研究人员（研究生和 博士后同事）提供海报展示。 这些 后者的资金将通过竞争授予年轻人， 美国机构的调查人员。

Although many "molecular biologist" may regard "metabolic regulation" as a solved problem, the field is far from dead, and in fact appears to be entering into a new an exciting phase. The field has matured from a descriptive science to one capable of integrating biochemical relationships and mechanisms in dynamic terms--approaching the complexity of living cells. Kinetic models with demonstrated predictive value have been made: the ultimate test of their usefulness and general validity. In the past, progress in biochemistry has been achieved primarily through the isolation and in-depth analysis of individual cellular components. Progress in the future may well depend upon the extent to which this wealth of information can be used in dynamic models which simulate metabolism in intact cells and organisms. Only when the reductionistic and holistic approaches converge, will we really begin to understand the complexities of metabolism in vivo. Despite the fundamental importance of the dynamic analysis of metabolic processes, the field today is diffuse and confused in the minds of most biochemists. Too many arbitrary and useless models fill the literature. Given enough assumptions, any metabolic system can be modeled, yet not necessarily reflect metabolism in vivo. The greater the volume of experimental data with which a model is consistent and by which it is challenged, the greater the probability that it describes reality and approaches a unique solution. A primary objective of this conference is to establish ground rules for the construction and use of various kinds of metabolic models. The proposed program will consist of symposia and poster sessions. Funds are requested for the travel of 40 invited speakers and convenors from the international research community to address various aspects of metabolic modelling, and for 20 or so young investigators (graduate students and postdoctoral associates) giving poster presentations. These latter funds would be awarded competitively to young investigators from United States institutions.