IRON PROTEINS AND HEMOCHROMATOSIS

拟议在耶路撒冷举行的会议将汇集 会议两个科学家论坛：血色病会议 铁超载的临床方面，以及铁蛋白会议， 代表最负盛名的基础研究研讨会在 铁的生物学 每一次会议通常都是在 另一年。 第四届血色病国际会议将在 1993年4月29日和30日，第11届国际 5月2日至7日举行的铁和铁蛋白质会议。 这些会议将首次联合组织和举行 在一个地方。 临床会议将回顾最近的进展 在6号染色体上血色病基因的鉴定中， 开发新的非侵入性方法来评估 铁超载，铁毒性机制的研究， 设计和测试新的口服有效的铁螯合药物。 基础研究的主题将包括转录和翻译 转铁蛋白和铁蛋白基因的调节， 转铁蛋白受体，铁的结构-功能关系 转铁蛋白-细胞和铁蛋白-细胞相互作用，以及 铁通过血脑和血睾丸屏障的转运。 将作出特别努力，招聘新加入的杰出科学家， 铁蛋白会议，并考虑新的方法来铁的研究 例如基因疗法治疗铁的潜力 超负荷，铁在正常和错乱的大脑功能中的作用， 细胞因子调节铁蛋白表达。 本申请的目的是 是让美国的科学家能够 或新兴的创造性研究人员参与这两个 会议，从而促进信息和想法的交流， 来自欧洲、日本和澳大利亚的其他顶尖科学家， 所有人的互利。

The proposed meeting in Jerusalem will bring together in tandem sessions two forums of scientists: the Hemochromatosis Conference on the clinical aspects of iron overload, and the Iron Protein meeting, representing the most prestigious symposium on basic research in the biology of iron. Each of these meetings is customarily held every other year. The Fourth International Conference on Hemochromatosis will take place on April 29 and 30, 1993 and will be followed by the 11th International Conference on Iron and Iron Proteins between the 2nd and 7th of May. For the first time these meetings will be jointly organized and held at a single location. The clinical meeting will review recent progress in the identification of the hemochromatosis gene on chromosome 6, the development of new non-invasive methods for assessing the severity of iron overload, research on the mechanism of iron toxicity, and the design and testing of new orally effective iron chelating drugs. Topics of basic research will include transcriptional and translational regulation of transferrin and ferritin genes, the cell biology of the transferrin receptor, structure-function relationships of iron proteins, transferrin-cell and ferritin-cell interactions, and the transport of iron across blood-brain and blood testis barriers. Special efforts will be made to recruit leading scientists new to the iron protein meetings, and to consider new approaches to iron research such as the potential of gene therapy for the treatment of iron overload, the role of iron in normal and deranged brain function, and cytokine regulation ferritin expression. The aim of this application is to make it possible for scientists from the U.S. who are established or emerging creative investigators to participate in the two conferences, thereby promoting exchange of information and ideas with other leading scientists from Europe, Japan and Australia, to the mutual benefit of all.