GORDON CONFERENCE--FIBRONECTIN AND MACROMOLECULES

细胞外粘附素，纤维连接蛋白，与细胞外粘连蛋白相互作用的范例 跨膜受体已被证明适用于许多黏附 系统。还有其他几种胞外糖蛋白 生物学特性，如纤维连接蛋白、层粘连蛋白、血栓反应蛋白、血管性血友病 Willebrand因子、纤维蛋白原/纤维蛋白、Vitronectin和 细胞肌动蛋白/替马菌素/六环鸟苷。每一个的主要结构 这些蛋白质是确定的，三维结构在 对一些人来说，这是一个进步。这将为研究……开辟新的可能性 功能。与此同时，人们也意识到，跨膜 纤维连接蛋白受体只是整合素家族中的一个成员 功能相关的同源细胞黏附受体。纤维连接蛋白 相关的大分子参与细胞的许多基本功能， 包括细胞黏附，细胞形状和分化的测定， 细胞迁移、细胞骨架组织和组织 细胞外基质。因此，纤维连接蛋白及其与之结合的分子 相互作用在胚胎发育、结缔组织组织、 止血，血栓形成，伤口愈合，免疫力的发展， 造血、恶变和肿瘤转移。这个 未来几年该领域面临的挑战是理解和 组织大量的新结构信息和设计 以此为基础的实验；了解其相对生物学重要性 几个看似多余的粘连系统；并应用新的 对人类疾病治疗的见解。1993年的戈登研究 会议将成为一个宝贵的论坛，介绍和讨论新的 信息，找出问题领域，并计划新的方法。

The paradigm of an extracellular adhesin, fibronectin, interacting with a transmembrane receptor has proven applicable to a number of adhesion systems. There are several other extracellular glycoproteins with biological properties like fibronectin, laminin, thrombospondin, von Willebrand factor, fibrinogen/fibrin, vitronectin, and cytotactin/tenascin/hexabrachion. The primary structures of each of these proteins are determined and three-dimensional structures are in progress for some. This will open up new possibilities for studies of function. In parallel has come the realization that the transmembrane receptor for fibronectin is only one member of the integrin family of functionally related, homologous, cell adhesion receptors. Fibronectin and related macromolecules are involved in many basic functions of cells, including cell adhesion, determination of cell shape and differentiation, cell migration, cytoskeletal organization, and organization of extracellular matrix. Thus, fibronectin and the molecules with which it interacts are important in embryogenesis, connective tissue organization, hemostasis, thrombosis, wound healing, development of immunity, hematopoiesis, malignant transformation, and tumor metastasis. The challenges to the field over the next several years are to comprehend and organize the large amount of new structural information and design experiments based upon it; learn the relative biological importance of the several seemingly redundant adhesion systems; and apply the new insights to the treatment of human diseases. The 1993 Gordon Research Conference will serve as a valuable forum to present and discuss new information, identify problem areas, and plan new approaches.