GORDON RESEARCH CONFERENCE--DNA REPAIR

请求为第四次戈登研究会议提供部分支助 哺乳动物DNA修复在1993年-一年两次的会议， 聚集了一群不同的科学家， 哺乳动物细胞中DNA的遗传调控以及 不完整和不准确的修复的后果。 本主题是关于 在评估与接触有关的风险方面特别重要 环境诱变和致癌危害，也是许多 对许多其他不同领域的兴趣，例如 个人的化疗药物的疗效，理论， 衰老，生化过程的进化分歧， 克隆人类基因，改变暴露反应。 会议 提供机会，在非正式场合， 一群科学家，他们经常发现自己并不处于同一个位置， 会议 与会者之间的讨论可能会导致一个 交流思想，技术和方法，这将使许多人受益 不同的研究项目和领域。 本次会议将包括9个 涉及正在取得进展的一系列领域的会议 并将在各领域的领导人举行会谈， 对直接领域的科学家，但对相关学科的科学家。 会议将涵盖染色质结构，修复和基因 转录，构建和使用位点特异性损伤，损伤- 诱导反应，调节对电离辐射损伤的反应， 人修复缺陷性疾病、转基因动物和 脊椎动物和植物的范围。 请求为差旅提供支助 以及来自美国和海外的主要参与者的会议费， 特别是年轻的调查员，否则他们无法参加。 支持外国参与者的必要性在一定程度上尤其重要。 重要的是保持一种国际贡献， 在过去的会议中很有价值，因为DNA修复领域 涉及欧洲和亚洲国家的许多主要参与者。

Support is requested, in part, for the fourth Gordon Research Conference on Mammalian DNA Repair in 1993 - a biannual conference which brings together a diverse group of scientists interested in the molecular and genetic regulation of DNA in mammalian cells and the biological consequences of incomplete and inaccurate repair. This topic is of particular importance in assessment of the risk associated with exposure to environmental mutagenic and carcinogenic hazards, and is also of much interest to many other disparate areas such as the variations among individuals of the efficacy of chemotherapeutic agents, theories of aging, evolutionary divergence of biochemical processes, and mapping and cloning human genes which modify response to exposures. The conference provides the opportunity for the interaction, in an informal setting, of a group of scientists who often do not find themselves at the same meeting. Discussions between the participants are likely to lead to an exchange of ideas, techniques, and approaches which will benefit many different research projects and areas. This meeting will include nine sessions covering a range of areas in which progress is being made rapidly and will feature talks by leaders in the fields aimed not only at scientists in the immediate area but those in related disciplines. The sessions will cover chromatin structure, repair, and gene transcription, construction and use of site-specific lesions, damage- inducible responses, regulation of response to ionizing radiation damage, human repair deficient disorders, transgenic animals, and repair in a range of vertebrates and plants. Support is requested towards the travel and conference fees for key participants from the U.S. and overseas, especially young investigators, who otherwise would be unable to attend. The need to support foreign participants, in part, is particularly important to preserve an international contribution which has been very valuable in past conferences, and because the field of DNA repair involves many major participants in European and Asian countries.