GORDON CONFERENCE ON PROTEASES/INHIBITORS

该申请要求资助1992年戈登会议， 蛋白酶及其抑制剂。 本次会议的重点是一个平衡的 一组关于蛋白酶机制和功能的报告， 这些蛋白酶的抑制剂。 在将列入《公约》的8届会议中， 会议，两个是专门的蛋白酶机制的细节（本 Dunn，主席），2至血浆丝氨酸蛋白酶抑制剂（Serpins） （Robin Carrell，主席），蛋白酶的一个效应子模块（Frank Castellino，主席），一个是蛋白酶加工和酶原激活 (Guy Salvesen，主席），一对病毒蛋白酶及其抑制剂 包括艾滋病毒（埃克哈特维默，主席）， 为后期开发的及时主题开放（主席S.V. Pizzo）。 在撰写本文时，约有25位发言人承诺， 预计是32。 演讲的重点是蛋白酶 在凝血、纤维蛋白溶解和炎症中的作用及其抑制剂。 这一重点领域应特别吸引国家的心， 肺和血液研究所社区，但介绍了病毒蛋白酶 包括艾滋病毒在内的一个领域，将吸引广泛的利益群体， 讨论蛋白质水解的一般机制。 鉴于专业知识和 会议主席皮佐博士的利益，他的会议将是 预计将集中在血浆蛋白酶及其抑制剂。

This application requests funding to support the 1992 Gordon Conference on Proteases and Their Inhibitors. The focus of this conference is a balanced group of presentations on both protease mechanism and function and the inhibitors of these proteases. Of the 8 sessions to be included In the conference, two are dedicated to specifics of protease mechanisms (Ben Dunn, Chairman), 2 to serine protease inhibitors of the plasma (Serpins) (Robin Carrell, Chairman), one to effector modules of proteases (Frank Castellino, Chairman), one to protease processing and zymogen activation (Guy Salvesen, Chairman), one to viral proteases and their inhibitors including HIV (Eckhardt Wimmer, Chairman) and one session has been left open for late developing timely topics (S.V. Pizzo, Chairman). At this writing, about 25 speakers are committed and the final number expected is 32. The emphasis of the presentations is on proteases involved in coagulation, fibrinolysis and inflammation as well as their inhibitors. This area of emphasis should appeal particularly to the National Heart, Lung and Blood Institute community but presentations in the viral protease area, including HIV, will appeal to a wide community of interest as will discussions of general mechanisms of proteolysis. Given the expertise and interests of the conference chairman, Dr. Pizzo, his session will be expected to focus on plasma proteases and their inhibitors.