IOWA STATE UNIVERSITY ANIMAL RESOURCE IMPROVEMENT

爱荷华州立大学遵守动物福利法，但 它没有得到美国认证协会的认可 实验动物保护协会(AAALAC)。爱荷华州的长期目标 大学将因其动物设施而获得AAALAC认证。 这项拨款提案的具体目标是：1)改善选定的 现有设施，用于安置小型实验动物 目的是提供足够的空间，使所有小型实验室 ISU的动物可以被安置在符合AAALAC标准的垃圾箱设施中 标准；2)改善执行支助股使用的选定外科设施 研究人员让NIH的所有实验性手术都得到了支持 研究将在符合AAALAC标准的设施中进行；3) 将灵知生菌研究实验室的电力服务升级为 减少对动物的危害和传染病的传播风险 发生电源故障时的代理。 具体目标1将通过改造实验动物来实现 兽医综合体和基尔迪大厅的容纳设施。 这些翻新的设施以及最近翻新的两只动物 ISU的拘留设施，两座将容纳动物的新建筑 正在建造的停放设施，以及拟建的 由国家出资改建一个额外的设施应该可以让所有 ISU的实验动物将被安置在AAALAC批准的设施中。 具体目标2将通过改造两个实验项目来实现 手术区。这些翻新的区域和手术设施 在兽医学院将允许所有实验性的 为NIH进行的手术支持在ISU进行的研究 AAALAC批准的设施。这项计划将允许逐步淘汰 三个不合格的外科设施。第三个具体目标 将通过提供应急发电机和升级 为所在的研究实验室提供电力服务 灵知生物动物。这对于确保持续的空气供应是必要的 至正压安全壳隔离器，这对于 动物的生存和实验动物的遏制 引入了病原体。

Iowa State University is in compliance with the Animal Welfare Act, but it is not accredited by the American Association for the Accreditation of Laboratory Animal Care (AAALAC). A long term objective of Iowa State University is to receive AAALAC accreditation for its animal facilities. the specific aims of this grant proposal are: 1) to improve selected existing facilities for housing small laboratory animals with the purpose of providing sufficient space so that all small laboratory animals at ISU could be housed bin facilities that meet AAALAC standards; 2) to improve selected surgical facilities used by ISU researchers so that all experimental surgeries for NIH supported research will be performed in facilities that meet AAALAC standards; 3) to upgrade electrical service to the gnotobiotic research laboratory to reduce the risk to the animals and the risk of spread of infectious agents in the event of a power failure. Specific aim 1 would be accomplished by renovating laboratory animal holding facilities in the veterinary Medicine Complex and Kildee Hall. These renovated facilities along with two recently renovated animal holding facilities at ISU, two new buildings that will contain animal holding facilities which are being constructed, and the proposed remodeling of one additional facility at state expense should allow all laboratory animals at ISU to be housed in AAALAC approved facilities. Specific aim 2 will be accomplished by renovating two experimental surgery areas. These renovated areas along with the surgical facilities in the College of Veterinary Medicine will allow all experimental surgeries performed for NIH supported research at ISU to be performed in AAALAC approved facilities. This plan will allow for the phasing out of three surgical facilities which are substandard. The third specific aim would be accomplished by providing an emergency generator and upgrading the electrical service to the research laboratory which houses gnotobiotic animals. This is necessary to ensure a continuous air supply to the positive pressure containment isolators which is essential for the survival of the animals and the containment of experimentally introduced pathogens.