LINKAGE ANALYSIS AND MULTIPLE LOCI

这项研究试图调查目前主基因的研究方法 通过链接研究实现本地化，并开发新的方法 恰如其分。将特别注意疾病的局部化 精神错乱。估计预期信息量的一般方法 将开发特定谱系结构中的可用资源，以便 即使对于复杂的性状，也有可能评估 进行连锁性研究。 我们将研究两个基因座的LOD评分的经典方法 为了检验该方法的威力，对重组分数的估计 以及准确估计数据所需的样本量。 重组分数。将对各种家庭结构进行审查，以 制定有效绘制地图的策略。这些研究将被延长 三个基因座之间的连锁。特别是，确定的问题 将对基因顺序进行检查。论三个轨迹的权力论 分析还将考虑推断干扰所需的样本大小 或者基因转化。 将进行一项模拟研究，以检查遗传分析 常见病。特别是，不允许零星的 在家系和连锁分析上都会出现这种疾病 考虑过了。

The research seeks to investigate the current methods of major gene localization through linkage studies and to develop new methods where appropriate. Particular attention will be paid to localizing disease loci. General methods for estimating the expected amount of information available in a particular pedigree structure will be developed, so that even for complex traits, it is possible to evaluate the utility of performing a linkage study. The classical methodology of LOD scores for two loci will be investigated to examine the power of the method, the estimates of recombination fraction obtained and the sample sizes required for accurate estimation of the recombination fraction. Various family structures will be examined to develop strategies for efficient mapping. These studies will be extended to linkage between three loci. In particular, the problem of determining gene order will be examined. Discussions of power for the three loci analysis will also consider the sample sizes required to infer interference or gene conversion. A simulation study will be undertaken to examine the genetic analysis of common disorders. In particular, the effect of not allowing the sporadic occurrence of the disorder on both pedigree and linkage analysis will be considered.