EPSRC Centre for Doctoral Training in Molecular Analytical Science

研究领域概述分析科学是任何基础或应用科学研究计划成功的关键，并支撑着英国传统上强大但在全球面临越来越多挑战的广泛领域的工业进步和生产。华威在通过CDTS进行最高质量的学生培训以及创造性的仪器和理论分析科学方面拥有广泛的记录，这构成了分子分析科学中心(MASC)这一提议的背景。MASC将专注于开发和应用分子分析科学方法来解决6个主题的问题1.复杂矩阵中的测量、传感和提取2.高级定量分析3.复杂系统中的分子结构和稳定性4.制药、生物制药、农业科学、个人护理中设计质量的新技术5.表征和开发功能生物分子组件6.优化和理解复杂系统动力学的分析科学需要博士科学家，MASC将制作许多报告可以引用来支持高质量跨学科分子分析科学培训的国家重要性。例如：*“学科的健康：提交给英国研究基地资助者论坛的2008年年度报告”报告说，物理和分析科学家短缺，统计/数学和生物技术短缺。*2009年的《英国化学研究国际评论》指出，英国的生物分析研究得到了国际认可，并处于应对社会最大挑战的有利地位，强调了这一领域的持续重要性。*RSC 2006年的一份报告“分析和测量科学平台知识转移计划-调查结果”指出，“分析和测量科学不仅其性质极其多样化和影响深远，而且它们本身也是一项大规模的经济活动。……分析部门有70亿GB的营业额，雇佣了20万人”。CDT提案的一个驱动因素是，不仅需要对现有技术进行培训，还需要开发新技术，使我们能够解决目前尚未解决的挑战(例如，很难证明潜在的仿制药确实是“生物相似的”)。华威分析科学界欣然接受技术发展的挑战，在新仪器和理论方法开发和应用方面的记录证明了这一点。MASC将采用的方法新的CDT将受益于成熟的基于跨学科队列的培训文化，在MOAC DTC的10年生命周期中发展和完善，以及长期运行的华威分析科学硕士项目，并将嵌入由RCUK科学和创新基金创建的研究社区，该基金于2008年成立了虚拟的华威分析科学中心。MASC的学生将在第一年进行跨学科的硕士课程，最后是两个不同学科的小型研究项目，包括理论和实验研究。在第二至第四年，他们将在世界领先的水平上开展一个多学科、多部门的分析科学博士研究项目，并辅之以可转移的技能培训。每个项目都将涉及技术开发和应用，并有完整的产业参与。在攻读硕士和博士期间，学生们将有机会在工业环境中工作，并体验国际实验室，以增强他们对不同背景下的科学过程的理解。国际借调的对象要么是华威的战略合作伙伴，要么是监管者的目标合作者。

OVERVIEW OF RESEARCH AREA Analytical science is key to the success of any fundamental or applied science research programme, and underpins industrial progress and production in a wide range of areas in which the UK is traditionally strong but where it faces increasing challenges globally. Warwick has an extensive track record both in the highest quality student training through CDTs and in creative instrumental and theoretical analytical science, which forms the background to this proposal for a Molecular Analytical Science Centre (MASC). MASC will focus on developing and applying molecular analytical science methods to problems in 6 themes 1. Measurement, sensing, and extraction in complex matrices 2. Advanced quantitative analysis 3. Molecular structure and stability in complex systems 4. New techniques for Quality by Design in pharmaceutical, biopharmaceutical, agri-science, personal care 5. Characterising and exploiting functional biomolecular assemblies 6. Analytical science for optimising and understanding dynamics in complex systems NEED FOR THE DOCTORAL SCIENTISTS THAT MASC WILL PRODUCE Many reports can be quoted to support the national importance of high quality cross-discipline molecular analytical science training. For example: * The "Health of disciplines: annual report 2008 to the UK research base funders' forum" reported a shortage in physical and analytical scientists as well as shortages in statistics/mathematics and biotechnology. * The 2009 "International Review of UK Chemistry Research" stated that bioanalytical research in the UK is internationally recognised and well-placed to tackle society's greatest challenges, emphasising the continued importance of this area. * A 2006 report for the RSC "Analytical and Measurement Sciences Platform Knowledge Transfer Plan - Survey Findings" noted that "not only are the analytical and measurement sciences extremely diverse and far-reaching in their nature but they are also a massive economic activity in [their] own right. ... analytical sector has £7bn turnover and employs 200,000 people". A driver for this CDT proposal is that the need is not simply for training in existing techniques but also for developing new techniques that will allow us to solve currently open challenges (e.g. the difficulty of proving that a potential generic biopharmaceutical is indeed 'biosimilar'). The Warwick analytical science community embraces the challenge of technique development, as evidenced by a track record in novel instrument and theoretical method development and application. APPROACH TO BE ADOPTED BY MASC The new CDT will benefit from the well-established cross-discipline cohort-based training culture, developed and refined over the 10-year life of the MOAC DTC and the long-running Warwick analytical science MSc programmes, and will be embedded in the research community created by the RCUK Science and Innovation funding that formed the virtual Warwick Centre for Analytical Science in 2008. The MASC students will undertake a cross-discipline MSc programme in year 1, concluding with 2 mini research projects in different disciplines, including both theoretical and experimental research. In years 2-4 they will perform a multi-disciplinary, multi-sector analytical science PhD research project, at a world-leading level, complemented by transferable skills training. Each project will involve technique development and application, with integrated industrial involvement. Students will enjoy the benefit of opportunities during both MSc and PhD to work in an industrial environment and also to experience an international laboratory to enhance their understanding of the scientific process in different contexts. The international secondments will either be to strategic partners of Warwick or to targeted collaborators of the supervisors.