EPSRC Centre for Doctoral Training in Physical Sciences Innovation in Chemical Biology for Bioindustry and Healthcare

化学生物学是英国的一个具有战略意义的重要研究领域，它着眼于开发和应用新的工具和技术来研究生物系统中的分子相互作用。化学生物学的研究生培训将在推动创新和改变生物技术和医疗技术，农业科学和个人护理领域的设计过程中发挥至关重要的作用，并刺激在英国创建新的初创企业。为了满足这些技能，必须培养新一代化学生物学博士毕业生，他们能够连接科学和商业/工业部门，同时仍然能够在物理和生命科学界面上工作，允许多种形式的翻译活动。这一关键的技能差距将由新的CDT“生物工业和医疗保健化学生物学物理科学创新”解决，该项目将在未来5年内培养90多名博士生，由世界领先的化学生物学研究所（ICB）的多学科环境支持化学生物学的多学科性质以及它对在物理和化学之间的界面工作的学生构成的翻译挑战。与生命科学以及学术和商业世界之间的联系使得CDT结构非常适合支持学生发展。这种多学科的培训在这个接口是至关重要的，使英国能够适应在生活，个人护理和农业科学部门的技术变革的步伐。此外，与支持这些新技术的研究相关的特定社会，伦理，工业和创业方面需要在CDT背景下最有效地提供定制方法。ICB及其战略合作伙伴共同制定了一项为期4年的培训和研究计划（MRes + 3年博士学位），该计划将提供多学科转化研究，研究领导力，科学传播，精神病学和商业技能的第一手经验。这包括Fab实验室类型环境中的技术开发、与BBC合作的科学传播培训、行业主导的创新研讨会、创业培训以及针对学生主导的知识产权的“龙穴”型竞赛。此外，我们将实施EVOLVE计划，这是一个为个人量身定制的旅程，旨在提供创业活动，政策制定，媒体/宣传，工业研究，或在国际学术机构内进行研究，以实现CDT学生选择的特定目标。这一紧密联系的学生群体将得到来自世界各地的120多个研究小组的综合社区的支持。帝国理工学院的三个学院这些活动将通过新的专门的转化分子研究实验室（LTMR）得到进一步加强。CDT研究计划中出现的工具和技术将通过开发新的功能筛选、靶点验证分析、预测性人工仿生模型以及提供对潜在新靶点的见解来支持药物、农用化学品和个人护理产品的发现。他们还将协助和推进基础生物学，诊断技术，用于生物分子无标签跟踪的光学指纹技术，具有定制释放动力学的智能生物递送系统，小分子膜蛋白筛选测定，药物分子非特异性结合的体外筛选，生物标志物的发现，并提供一套新的定量动态分子信息。

Chemical Biology is a strategically important area of research for the UK that looks at the development and application of novel tools and techniques for the study of molecular interactions in biological systems. Graduate training in Chemical Biology will play a crucial role in driving innovation and transforming the design process in the biotech and medical technology, agri-science and personal care sectors, as well as stimulating the creation of new start-up enterprises in the UK. In order to meet these skills a new generation of PhD graduates in Chemical Biology must be trained who are able to connect the scientific and commercial/industrial sectors whilst still being supremely well equipped to work across the Physical and Life Sciences interface, allowing for multiple forms of translational activity. This crucial skills gap will be addressed by the new CDT in "Physical Sciences Innovation in Chemical Biology for Bioindustry and Healthcare" which will train > 90 PhD students over the next 5 years, supported by the multi-disciplinary environment of the world leading Institute of Chemical Biology (ICB) at Imperial College.The multidisciplinary nature of Chemical Biology and the translational challenges that it poses to students working at the interface between the physical and life sciences and between the academic and commercial worlds makes a CDT structure highly appropriate for supporting student development. Such multi-disciplinary training at this interface is vital to enabling the UK to adapt to the pace of technological change in the life, personal care and agri-sciences sectors. Furthermore, the particular societal, ethical, industrial and entrepreneurial aspects associated with research that will underpin these new technologies requires a bespoke approach that is most effectively delivered in a CDT context. The ICB and its strategic partners have together crafted a 4-year training and research programme (MRes + 3 Year PhD), which will provide first-hand experience of multi-disciplinary translational research, research leadership, science communication, entrepreneurialism and business skills. This includes technology development in Fab lab type environments, science communication training in collaboration with the BBC, industry led innovation workshops, entrepreneurship training and a "Dragons Den"-type competitions for student-led IP. In addition, we will implement the EVOLVE programme, a journey tailored to the individual designed to give experience of entrepreneurial activities, policy making, media/outreach, industrial research, or research within international academic institutions in the context of achieving a particular goal selected by the CDT student.This closely knit cohort of students will be supported by an integrated community of over 120 research groups from all three faculties across Imperial College. These activities will be further enhanced by the new dedicated Laboratory for Translational Molecular Research (LTMR).The tools and technologies that will emerge from the research programme of the CDT will support drug, agrichemical and personal care product discovery through the development of new functional screens, target validation assays, predictive artificial biomimetic models and by providing insights into potential novel targets. They will also assist and advance basic biology, diagnostic technologies, optical finger printing technologies for label free tracking of biomolecules, smart biodelivery systems with tailored release kinetics, small molecule-membrane protein screening assays, in-vitro screens for the non-specific binding of drug molecules, the discovery of biomarkers and offer access to a new suite of quantitative dynamic molecular information.