PONTINE LESIONS AND STATE-RELATED RESPIRATION

我将检查上呼吸道肌肉(UA Mm)与 清醒和呼吸状态下的横隔膜活动和换气 睡吧。与状态相关的肌肉变化和呼吸反应 刺激也将被研究。猫将被长期植入以记录 标准睡眠参数和肌肉。关于通风的研究，猫 也会准备慢性气管瘘，并在 插管和控制住了。UA mm函数中与状态相关的更改有 与睡眠呼吸暂停的发病有关，睡眠呼吸暂停是一种危及生命的综合征 最常见的是成年男性。进一步阐明UA MM紧张症的作用 通常发生在反常睡眠(最频繁和最严重的时候 我们将在患有呼吸暂停的猫身上重复上述所有研究 接受桥脑损毁，废除了反常睡眠的张力。这 准备，这是校长广泛研究的 研究人员，此前已被证明在研究紧张症的作用方面很有用 在生热作用中与状态相关的变化，应该同样对 确立了紧张症在与国家相关的变化中的重要性 呼吸。

I will examine the relationship between upper airway muscle (UA mm), diaphragmatic activity and ventilation during all states of waking and sleep. State-related changes in muscle and ventilatory responses to stimuli will also be studied. Cats will be chronically implanted to record standard sleep parameters and muscles. For studies of ventilation, cats will also be prepared with a chronic tracheal fistula and recorded while intubated and restrained. State-related changes in UA mm function are implicated in the pathogenesis of sleep apneas, a life-threatening syndrome most common in adult men. To further clarify the role of UA mm atonia which normally occurs in paradoxical sleep (when most frequent and severe apneas occur) we will repeat all the above studies in cats which have received pontine lesions abolishing the atonia of paradoxical sleep. This preparation, which has been extensively studied by the principal investigator, has previously proved useful in studying the role of atonia in state-related changes in thermogenesis and should be equally useful in establishing the importance of atonia in state-related changes in respiration.