ROLE OF THE LOCUS CERULEUS IN SENSORIMOTOR CORTEX INJURY

当前提案的长期目标旨在提供合理的 在现有康复治疗中使用的药物疗法 促进丧失行为能力恢复的程序。近期 有证据表明，儿茶酚胺的激动剂和拮抗剂， 尤其是去甲肾上腺素，在加速过程中起着重要作用， 延缓或逆转皮质损伤后功能的恢复。 然而，对去甲肾上腺素能参与程度的直接测试 缺乏系统，即蓝斑。目前的建议 通过将去甲肾上腺素局部注入不同的大脑来解决这个问题 单侧感觉运动皮质损伤后的终末区 蓝斑的视野投射部位。为了进一步证实 在蓝斑的作用下，6-羟色胺会对该核团造成损害 在感觉运动皮质损伤和随后的局部微量输注之前 东北地区。这些治疗的效果将与程度相关 行为功能的恢复。

The long term objectives of the current proposal aim at providing rational pharmacological therapies to be used within existing rehabilitation procedures to promote recovery of lost behavioral capacity. Recent evidence has indicated that agonists and antagonists of catecholamines, in particular norepinephrine, pay an important role in accelerating, retarding, or reversing recovery of function following cortical injury. However, a direct test of the extent of involvement of the noradrenergic system, i.e., the locus ceruleus, is lacking. The present proposal addresses this problem by localized infusions of NE into various brain areas following a unilateral sensorimotor cortex injury that are terminal field projection sites of the locus ceruleus. To further substantiate the role of the locus ceruleus, 6-OHOA lesions of this nucleus will be induced prior to sensorimotor cortex injury and subsequent localized microinfusions of NE. The effect of these treatments will be correlated with the extent of recovery of behavioral function.