EFFECTS OF PERINATAL PHENCYCLIDINE IN THE RAT

苯环利定(PCP)是美国一种重要的滥用药物 各州。五氯苯酚的使用量自1981年以来一直在增加，特别是 在育龄妇女中。在过去的几年里，它 很明显，产前接触五氯苯酚会产生长期的 运动和行为异常，可能是不可逆转的 人类。拟议研究的目标是建立一个 用于描述病理生理学特征的动物模型 围产期发育和行为的变化 接触五氯苯酚。具体的目标函数将基于 根据已知的对人类产前接触五氯苯酚的影响。 幼年动物的身体和行为发育 以及成年人的行为将被调查。关键人物 胎儿和新生儿暴露在空气中的脆弱时期 五氯苯酚将被确定。将进行生化测量 为了确定小区数量或小区大小是否受到影响 围产期暴露在中枢神经系统中 五氯苯酚。垂体-肾上腺轴的完整性将被测试为 初步研究表明，新生儿糖皮质激素水平 因产前暴露而减少。假设 母亲的后代的性别分化发生了变化 收到的五氯苯酚将通过研究生殖和 非生殖性二形性行为。的发展。 动物模型对于确定如何产前是必不可少的 暴露于五氯苯酚会产生这样的长期行为影响 人类。对潜在的基本机制的了解 产生这些影响的行动势在必行 制定策略，以预防和可能治疗 产前接触这种主要药物的严重后遗症 虐待。

Phencyclidine (PCP) is an important drug of abuse in the United States. The use of PCP has been increasing since 1981, especially among women of childbearing age. In the last few years it has become clear that prenatal exposure to PCP produces long-term motor and behavioral abnormalities that may be irreversible in humans. The goal of the proposed research is to establish an animal model with which to characterize the pathophysiological changes in development and behavior produced by perinatal exposure to PCP. Specific target functions will be studied based upon the known effects of prenatal exposure to PCP in humans. Both physical and behavioral development in young animals as well as behavior in adults will be investigated. The critical periods of vulnerability of the fetus and neonate to exposure to PCP will be determined. Biochemical measurements will be made in order to ascertain whether cell number or cell size is affected inthe central nervous system as a result of perinatal exposure to PCP. The integrity of the pituitary-adrenal axis will be tested as preliminary studies suggest that neonatal glucocorticoid levels are decreased as a result of prenatal exposure. The hypothesis that sexual differentiation is altered in offspring whose mothers received PCP will be tested by studying reproductive and nonreproductive sexually dimorphic behavior. The development of an animal model is essential in order to determine how prenatal exposure to PCP produces such long-term behavioral effects in humans. Knowledge of the underlying fundamental mechanisms of action by which these effects are produced is imperative in order to develop strategies with which to prevent and possibly treat the profound sequelae of prenatal exposure to this major drug of abuse.