CAROTID BAROREFLEX CONTROL IN NORMO- AND HYPERTENSION

压力感受性反射在高血压中的作用是 争议 拟议的研究将集中在三个方面 高血压患者压力感受性反射功能的变化 高血压的压力反射控制，血管活性 正常人、高血压和颈动脉窦激素释放 血管阻力和容量功能的反射控制 高血压 研究将在高血压犬中进行 颈动脉窦区域长期孤立。 结果 将高血压狗与血压正常的对照进行比较。 将审查是否可能减少遵守 颈动脉窦本身也可能导致功能丧失， 高血压的压力反射控制 压力感受器反射的能力 为了适应当前压力的快速变化， 重置过程将在高血压慢性犬中进行评价。 将检验压力感受性反射的变化 所见的功能发生在受体水平; 将使用传入颈动脉窦神经活动的测量 以评估受体神经特征的变化。 抑制 通过对侧窦的作用，颈动脉窦将 评估高血压。 颈动脉压力反射释放 将在正常和高血压患者中研究血管活性激素 狗 有待检验的假设是， 这些血管活性激素已知是在 生理压力有助于维持升高的 高血压的血压水平。 待研究的激素包括 加压素去甲肾上腺素和β-内啡肽 压力反射控制 将检查全身血管阻力。 整个 将测量全身压力-流量关系， 在心脏搭桥术的高血压犬中进行了急性比较。 中 进一步的一系列实验，颈动脉压力感受性反射的控制， 将测量全身血管顺应性。 的假设 要测试的是，降低血管顺应性和减少 顺应性的反射性变化可以解释动脉改变 高血压的压力调节 在另一系列建议中， 实验，颈动脉窦反射控制全身血管 容量，特别是无应力血管容积，将 在心脏搭桥术的高血压犬中进行评估。 最终 实验将评估，无论是慢性和急性， 局部血管阻力和容量的差异性变化 在高血压中。 这些实验将提供新的和 关于传入和 高血压时传出压力感受性反射控制

The role of the baroreceptor reflex during hypertension is controversial. The proposed research will focus on three aspects of baroreflex function in hypertension: changes in receptor function in hypertension, baroreflex control in vasoactive hormone release in normo- and hypertension, and carotid sinus reflex control of vascular resistance and capacity functions in hypertension. The studies will be performed in hypertensive dogs with chronically isolated carotid sinus regions. Results from hypertensive dogs will be compared to normotensive controls. The possibility will be examined that a reduced compliance of the carotid sinus itself could contribute to a loss of functional baroreflex control in hypertension. The ability of the baroreflex to adapt to rapid changes in prevailing pressure, the rapid resetting process will be evaluated in hypertensive chronic dogs. The hypothesis will be tested that the changes in baroreflex function seen are occurring at the level of the receptor; measurement of afferent carotid sinus nerve activity will be used to assess changes in receptor-nerve characteristics. Inhibition of the carotid sinus by the action of the contralateral sinus will be assessed in hypertension. Carotid baroreflex release of vasoactive hormones will be studied in normo- and hypertensive dogs. The hypothesis to be tested is that increased release of these vasoactive hormones known to be released during physiological stresses contributes to the maintenance of elevated pressure levels in hypertension. Hormones to be studied include vasopressin, nor-epinephrine and B-endorphin. Baroreflex control of systemic vascular resistance will be examined. The entire systemic pressure-flow relationship will be measured and compared acutely in hypertensive dogs on cardiac bypass. In a further series of experiments, carotid baroreflex control of systemic vascular compliances will be measured. The hypothesis to be tested is that reduced vascular compliances and diminished reflex changes in compliance can account for the altered arterial pressure regulation in hypertension. In another series of proposed experiments, carotid sinus reflex control of systemic vascular capacity, and particularly unstressed vascular volume, will be assessed in hypertensive dogs on cardiac bypass. The final experiment will assess, both chronically and acutely, the differential changes in regional vascular resistance and capacity in hypertension. These experiments will provide new and important information regarding the mechanisms of afferent and efferent baroreflex control during hypertension.