NEW BIOMEDICAL INTERFACE MATERIALS

拟议的研究旨在实现 等离子体的突出潜力(射频辉光放电) 制备新型生物医用界面的合成方法 材料。成功的超薄界面材料将使 在生物功能方面需要做出重大改进， 和/或现有的血液和软组织相容性 生物医学材料。 现有生物材料的最佳体积性能很少 与最佳表面(界面)属性一致。 因此，任何改进都取决于以下能力 优化材质的表面，而不会对其产生不利影响 批量属性。通过等离子体合成的表面改性是 一种表面特定的方法，本质上适合于实现这些 目标，有广泛的血液或软组织接触 材料。具体地说，我们建议(1)合成疏水化合物 和亲水性超薄(小于0.5微米)涂层，用作 生物医学衬底上的界面材料，包括 金属、半结晶塑料和弹性体；(2)评估 等离子体合成方法在表面制备中的潜力 特殊的化学功能，如胺和羧基 基团，适合于固定特定分子以创建 新型生物活性生物材料；(3)体外评价 生物活性、体外血液相容性和体内 表面改性材料的生物相容性。 在不同的衬底上合成的每一种新型表面将 进行全面的物理和化学表征。 这将使每个曲面能够通过 调整等离子体反应条件。重点是 在拟议的研究中，重点是调查基础 和基础研究方面的方法，预计 这最终将导致大量的发现， 易于转让的创新和方法 到各种生物医学假肢设备。

The proposed studies are directed toward realizing the outstanding potential of plasma (radiofrequency glow discharge) synthesis methods for preparing new biomedical interface materials. Successful ultrathin interface materials will enable significant improvements to be made in the biological function, and/or the blood and soft-tissue compatibilities of existing biomedical materials. The optimum bulk properties of existing biomaterials are rarely coincident with optimum surface (interface) properties. Consequently, any improvement is dependent upon the ability to optimize the material's surface without adversely affecting its bulk properties. Surface modification through plasma synthesis is a surface specific approach inherently suitable for achieving these goals, with a wide range of blood or soft-tissue contacting materials. Specifically, we propose to (1) synthesize hyrdrophobic and hydrophilic ultrathin (less than 0.5 mu M) coatings for use as interface materials on biomedical substrates which include metals, semicrystalline plastics, and elastomers; (2) evaluate the potential of plasma synthesis methods for preparing surfaces with specific chemical functionalities, such as amines and carboxyl groups, appropriate for immobilizing specific molecules to create novel bioactive biomaterials; and (3) evaluate the in vitro bioactivity, in vitro blood compatibility, and in vivo biocompatibility of surface modified materials. Each of the synthesized novel surfaces on different substrates will undergo comprehensive physical and chemical characterizations. This will enable each surface to be optimized through the adjustment of the plasma reaction conditions. With the emphasis of the proposed studies focused on investigating the fundamental and basic research aspects of the approach, it is anticipated that this will lead ultimately to a significant number of discoveries, innovations and methodologies that will be transferrable readily to a variety of biomedical prosthetic devices.