EPIDEMIOLOGIC RESEARCH IN CANCER ETIOLOGY

我建议从事几项活动，所有这些活动都旨在阐明 肿瘤性疾病的病因学。 我将监督病例对照研究，以测试特定的病因 适用于该方法的假设。 第一个是胰腺癌， 与饮食和特应性疾病的关系，以及侵袭性（转移性或 通过子宫肌层浸润）子宫内膜癌与 外源性雌激素使用。 我将继续开发一个双胞胎癌症登记册， 乳腺癌、结肠癌和其他胃肠道恶性肿瘤的双胞胎研究 黑色素瘤和其它肿瘤。 我将对未受影响的双胞胎进行随访， 暴露，并利用加州基于人群的双胞胎登记处， 瑞典进行各种附属研究。 我将开始一项队列研究， 风险个人，旨在提高的决定因素和影响， 获得性良性色素性病变。 我将继续使用癌症和登记信息进行描述 研究，包括估计观察到的和预期的 配偶部位特异性癌症，居住在附近的人的发病率 有毒废物污染和特定疾病的地理集中地 双生子的一致性及其对家庭关系解释的意义 和遗传性。 最后，我将设计一个程序，以方便实验室调查 利用登记处双胞胎的材料;这样的计划可以 提供高质量流行病学研究设计的独特整合， 最先进的实验室技术

I propose to engage in several activities, all designed to illuminate the etiology of neoplastic disease. I will supervise case-control studies in test of specific etiologic hypotheses suited to that method. The first will be of pancreas cancer in relation to diet and atopic disease, and of aggressive (metastatic or invasive through the myometrium) endometrial cancer in relation to exogenous estrogen use. I will continue to develop a registry of twins with cancer and perform co-twin studies of breast cancer, colon and other GI cancer, malignant melanoma, and other neoplasms. I will perform follow up on unaffected twins in relation to their stated exposures, and utilize population-based twin registries in California and Sweden for various adjunct studies. I will begin a cohort study in high risk individuals designed to elevate the determinants and implications of acquired benign pigmented lesions. I will continue to use cancer and registry information for descriptive studies, including estimation of the observed and expected rates of conjugal site-specific cancer, of the incidence among those residing near geographic foci of contamination with toxic wastes, and of disease-specific concordance in twins and the implications for interpretation of familiality and heritability. Finally, I will design a program to facilitate laboratory investigations making use of material from twins in the registry; such a program could provide a unique integration of high quality epidemiologic study design and "state of the art" lab techniques.