EPIDEMIOLOGIC RESEARCH IN CANCER ETIOLOGY

我建议参加几个活动，所有这些活动都是为了照亮 肿瘤疾病的病因学。 我将监督病例对照研究，以检测特定的病因 适用于该方法的假设。第一个是#年的胰腺癌。 与饮食和特应性疾病以及侵袭性(转移性或 子宫肌层浸润性)子宫内膜癌与 外源性雌激素的使用。 我将继续建立一个患有癌症的双胞胎登记，并执行 乳腺癌、结肠癌和其他胃肠道癌、恶性肿瘤的联合研究 黑色素瘤和其他肿瘤。 我会对未受影响的双胞胎进行追踪 暴露，并利用加州基于人口的双胞胎登记和 瑞典提供各种辅助研究。我将在高中开始一项队列研究 旨在提高决定因素和影响的风险个人 获得性良性色素性病变。 我将继续使用癌症和注册信息进行描述性 研究，包括估计观察到的和预期的 婚姻部位特异性癌在居住在附近地区的人中的发病率 有毒废物污染的地理焦点和特定疾病的地理焦点 双胞胎的一致性及其对解释熟悉性的意义 和遗传能力。 最后，我将设计一个促进实验室调查的程序 利用登记中双胞胎的材料；这样的程序可以 提供高质量流行病学研究设计和 “最先进的”实验室技术。

I propose to engage in several activities, all designed to illuminate the etiology of neoplastic disease. I will supervise case-control studies in test of specific etiologic hypotheses suited to that method. The first will be of pancreas cancer in relation to diet and atopic disease, and of aggressive (metastatic or invasive through the myometrium) endometrial cancer in relation to exogenous estrogen use. I will continue to develop a registry of twins with cancer and perform co-twin studies of breast cancer, colon and other GI cancer, malignant melanoma, and other neoplasms. I will perform follow up on unaffected twins in relation to their stated exposures, and utilize population-based twin registries in California and Sweden for various adjunct studies. I will begin a cohort study in high risk individuals designed to elevate the determinants and implications of acquired benign pigmented lesions. I will continue to use cancer and registry information for descriptive studies, including estimation of the observed and expected rates of conjugal site-specific cancer, of the incidence among those residing near geographic foci of contamination with toxic wastes, and of disease-specific concordance in twins and the implications for interpretation of familiality and heritability. Finally, I will design a program to facilitate laboratory investigations making use of material from twins in the registry; such a program could provide a unique integration of high quality epidemiologic study design and "state of the art" lab techniques.