SEX HORMONES AND CANCER

拟议的研究旨在检查激动剂之间的相互作用。 和雌激素受体拮抗剂及其激活能力 受体与DNA结合状态的新建议平衡法 方法：研究方法。雄激素拮抗作用机制的新假说 雌激素的作用将在体外和体内进行测试。另外， 新发现的对类固醇激素明显耐药的研究 世界灵长类动物将被带到。血浆和组织的特性 类固醇水平以及与运输蛋白和受体的结合将 被执行。类固醇水平升高的可能性是 代谢类固醇的酶的缺陷的后果 受体将通过几种方法进行测试。这将包括 比较血浆和体液中的类固醇水平，如唾液， 类固醇代谢的组织学研究和类固醇动力学研究 活着。雄激素大量芳构化对雌激素的影响 发生在雄性松鼠猴身上的情况将被确定。特别是， 由此产生的大量雌激素的影响，连同 雄激素对青春期发育和季节性体重等事件的影响 变化，将被探索。(Y)

The proposed studies are designed to examine the interaction of agonists and antagonists with the estrogen receptor and their ability to activate the receptor to the DNA binding state using newly advised equilibrium methods. A new hypothesis for the mechanism of androgen antagonism of estrogen action will be tested both in vitro and in vivo. Additionally, studies of the apparent resistance to steroid hormones observed in New World primates will be carried out. Characterization of plasma and tissue steroid levels as well as binding to transport proteins and receptors will be performed. The possibility that the elevated levels of steroids are the consequence of defects in enzymes that metabolize steroids rather than receptors will be tested by several approaches. This will include comparison of steroid levels in plasma and body fluids such as saliva, studies of steroid metabolism by tissues, and study of steroid dynamics in vivo. The effects of massive aromatization of androgens to estrogens occurring in the male squirrel monkey will be determined. In particular, the influence of the resulting large amounts of estrogens, together with androgens on events such as pubertal development and seasonal weight changes, will be explored. (Y)