DRUG DESIGN FOR THE TREATMENT OF BLADDER INCONTINENCE

膀胱失禁是一种功能性疾病，其后果日益严重 为老龄化人口。 目前的治疗包括药物治疗， 对抗胆碱能输入膀胱。 有重度 药物治疗的缺点主要是由于缺乏特异性， 导致副作用的药物，其中许多不能 被老人容忍。 我们建议设计新的药剂， 有效且高度特异性。 利用rDNA技术， 重组受体特异位点的肽记忆分子 与细胞代谢机制相互作用，并因此模拟 受体作用 这将为理性提供一种新的方法 设计更具体的药物来解决自主神经系统的问题 神经系统

Bladder incontinence is a functional disorder with growing consequences for the aging population. Current therapy includes drug treatment aimed at antagonizing the cholinergic input to the bladder. There are severe drawbacks to drug therapy primarily due to the lack of specificity of the drugs which result in side effects, many of which cannot be tolerated by the elderly. We propose to design novel pharmaceutica agents which are both efficacious and highly specific. Using rDNA technologies we will design peptomementic molecules which reconstruct specific sites of receptor interaction with cellular metabolic machinery and, as a result, mimic receptor action. This will provide a new approach for the rational design of more specific drugs to address problems of the autonomic nervous system.