INFORMATION PROCESSING IN LAMINATED NEURONAL NETWORKS

我们计划继续我们对结构和功能的研究 神经元的性质及其在脑加工中的意义 感官信息。裸子鱼的电感系统 作为本研究的模型系统。我们将探索 神经细胞的结构和功能之间的关系 生理鉴定细胞的细胞内标记。vbl.使用 发射机或其发射机的小型、局部离子导入应用 各自的拮抗剂和通过同时细胞外记录 从单个神经元出发，我们打算研究网络特性， 是由于特定传送器的动作。 我们将重点关注三个中枢神经结构，即前起搏器 中脑的起搏核(PPN)、心脏的起搏器核(Pn) 延髓和电感觉外侧线叶(ELL)。 后脑勺。PPN包含两个功能不同前置马达 控制PN的放电频率的系统，一个用于 导致频率的平稳变化，以及一个引发突然的， 瞬时加速，或“啁啾”。这两种形式的频率 调制发生在对邻居电信号的响应中。 然而，鸣叫声只由高位的动物产生。 排名顺序。它们在男性中的发生是由以下因素促进的 睾丸激素，并被5-羟色胺抑制。5-羟色胺抑制剂， 因此，像甲基丝氨酸乙酯这样的物质能促进鸣叫。小的，本地化的 激动剂和拮抗剂在PPN及ITS中的应用 传入结构，并通过同时记录来自单个 与鸣叫相关的神经元，我们想要识别潜在的 其中的结构以及神经传递机制。 系统。 ELL是第一个电感处理站 信息。它含有身体上具有感受性区域的神经元 浮出水面。这些场的空间和时间动态是 通过递减的递归输入进行调制。这其中的机制是 可以在单细胞水平上通过局部研究调制 发射器及其拮抗剂的应用。

We plan to continue our studies of structural and functional properties of neurons and their significance for the processing of sensory information. The electrosensory system of gymnotiform fish serves as a model system for this research. We will explore relationships between the structure and function of neurons by intracellular labelling of physiologically identified cells. Using small, local iontophoretic applications of transmitters or their respective antagonists and by simultaneous extracellular recording from single neurons, we intend to study network properties that are due to the actions of specific transmitters. We will focus on three central nervous structures, the prepacemaker nucleus (PPN) of the midbrain, the pacemaker nucleus (PN) of the medulla, and the electrosensory lateral line lobe (ELL) of the hindbrain. The PPN contains two functionally different premotor systems to control the discharge frequency of the PN, one for inducing smooth changes in frequency, and one for eliciting abrupt, transient accelerations, or 'chirps'. Both forms of frequency modulations occur in response to electric signals of neighbors. Chirps, however, are exclusively produced by animals high in the rank order. Their occurrence in males is facilitated by testosterone and inhibited by serotonin. Serotonin inhibitors, such as methysergide, therefore, promote chirping. By small, local applications of agonists and antagonists to the PPN and its afferent structures, and by simultaneous recording from single neurons related to chirping, we want to identify the underlying structures as well as the mechanisms of neurotransmission in this system. The ELL is the first processing station for electrosensory information. It contains neurons with receptive fields on the body surface. The spatial and temporal dynamics of these fields are modulated by descending recurrent input. The mechanism of this modulation can be studied at the single-cell level by local application of transmitters and their antagonists.