FAMILIAL PSYCHIATRIC DISORDERS, ATTENTION, SCHIZOPHRENIA

本研究的主要目的是：1）确认报告， 在13岁之前发作精神分裂症的病例中， 精神分裂症和精神分裂症谱的聚集性增加 与成年人相比， 2）测试假设，某些措施， 注意力/信息处理（AIP）指数遗传易感性， 精神分裂症，3）确定AIP的分布 精神分裂症儿童一级亲属中的损害 与遗传传播的简单模型一致，以及4）测试 假设在某些AIP任务上的表现提供了一个有用的 精神分裂症患者分型的基础， 有和没有AIP损伤的精神分裂症儿童在他们的 抗精神病药治疗的短期反应，轻微 身体异常，精神分裂症谱系的家族聚集性 在正式思维障碍和频率的评级， 父母沟通异常 三个家庭各有七十五户 将研究以下群体：1）有精神分裂症儿童的家庭，2） 注意力缺陷障碍儿童的家庭，以及3） 没有精神疾病史的儿童。 岁的儿童进行了 注意力缺陷障碍提供了诊断特异性的测试 上述关系。 先证者将被诊断为结构化 诊断性访谈并根据形式思维障碍的程度进行评定。 将评估AIP性能并测量轻微物理异常 在所有先证者及其一级亲属中。 一级亲属 将进行结构化诊断访谈，使DSM III 精神分裂症谱系人格的I轴诊断和诊断 精神障碍和精神病倾向的心理测量。 家庭 精神分裂症病史将被确定为第二次， 三级亲属。 所有一级亲属的评估将 由不知道先证者诊断的工作人员进行。

The major objectives of this study are to: 1) confirm reports that cases with onset of schizophrenia prior to 13 years of age have an increased aggregation of schizophrenia and schizophrenia spectrum personality disorders in their families as compared to cases of adult onset schizophrenia, 2) test the hypothesis that certain measures of attention/information processing (AIP) index a genetic liability to schizophrenic disorder, 3) determine if the distribution of AIP impairments amongst the first degree relatives of schizophrenic children is consistent with a simple model of genetic transmission, and 4) test the hypothesis that performance on certain AIP tasks provides a useful basis for sub-typing schizophrenic patients by determining if schizophrenic children with and without AIP impairments differ in their short term response to neuroleptic treatment, incidence of minor physical anomalies, familial aggregation of schizophrenic spectrum disorders and in ratings of formal thought disorder and the frequency of parental communication deviance. Seventy five families in each of three groups will be studied: 1) families with a schizophrenic child, 2) families with an attention deficit disorder child, and 3) families with children who have no history of psychiatric disorder. Children with an attention deficit disorder provide a test of the diagnostic specificity of the above relations. Proband will be diagnosed with a structured diagnostic interview and rated on a measure of formal thought disorder. AIP performance will be evaluated and minor physical anomalies measured in all proband and their first degree relatives. First degree relatives will be administered structured diagnostic interviews to make DSM III axis I diagnoses and diagnoses of schizophrenic spectrum personality disorders, and psychometric measures of psychosis proneness. Family history of schizophrenic disorders will be determined for second and third degree relatives. All assessments of first degree relatives will be conducted by staff blind to the proband's diagnosis.