FEASIBILITY STUDY--TAXOL FROM PLANT CELL CULTURE

描述：（改编自申请人摘要）：长期目标 本申请的第一个目的是使用植物细胞培养物大量生产紫杉醇 过程 先前已被证实的新型生产力提升 将以全面和综合的方式制定战略。 的 第一阶段研究的具体目标是确定使用 植物细胞培养生产紫杉醇， 目的：（1）将愈伤组织的生产力转移到悬浮液中， 验证 (2)将对200多个细胞系进行紫杉醇和其他 紫杉烷类 (3)有利于快速增长的条件将会建立。 （四） 将研究生长和产物形成的动力学。

DESCRIPTION: (Adapted from applicant's abstract): The long term objective of this application is to produce taxol in bulk using a plant cell culture process. Previously proven as well as novel productivity-enhancement strategies will be developed in a comprehensive and integrated manner. The specific aim of phase I research is to establish the feasibility of using plant cell cultures for taxol production by accomplishing four enabling objectives: (1) Transfer of productivity from callus to suspension will be verified. (2) Over 200 cell lines will be screened for taxol and other taxanes. (3) Conditions favoring rapid growth will be established. (4) Kinetics of growth and product formation will be studied.