MAGNETIC MICROCLUSTERS FOR MRI CONTRAST AGENTS

人们发现了一类新的材料，这种材料表现出非磁性 行为处于其本机(子50A)状态，但当组合成 直径大于500A的磁体表现出超顺磁性行为。材料： 该类型可制备为可生物降解的500A团簇，注入 患者并用作安全、无毒、可降解的MRI造影剂。一个 提出了利用这些磁性团簇作为试剂的研究计划 对于MRI对比度，构建各种大小的集群以排除大小 特定器官投药在MRI上的对比及60赫兹的研究 以及这些团簇的Rp磁场响应随团簇大小、时间、pH的变化 和温度。 Omni Quest承认有必要进行体内测试来确定 它的研究的可行性，虽然这样的计划在 一家“小企业”--一家生物企业--第一阶段提案的局限性 将对候选材料进行分析并制定战略计划 完成体内测试已经到位。 基于第一阶段的成功，Omni Quest已经进入 与重要国际机构达成研究合作协议 制药公司和研究中心有能力和 打算在动物身上进行活体试验。这些机密文件 关系将在本文件的受保护部分内披露 仅限提案。

A novel class of material has been discovered that exhibits non-magnetic behavior in its native (sub 50A) state, but when assembled into clusters of above 500A in diameter exhibits superparamagnetic behavior. Materials of this type can be prepared as biodegradable 500A clusters, injected into patients and used as safe, non-toxic, degradable MRI contrast agents. A research program is proposed to utilize these magnetic clusters as agents for MRI contrast, to build clusters of various sizes for size exclusion delivery to specific organs for contrasting in MRI and to study the 60Hz and RP magnetic field response of these clusters vs. cluster size, time, pH and temperature. Omni Quest acknowledges the need for in vivo testing to determine the viability of its research and while such a program is not feasible within the limits of a Phase I proposal by a "small business", a biological analysis of candidate materials will be conducted and a strategic plan for accomplishing in vivo testing is in place. Based upon a successful Phase I, Omni Quest has already entered into research collaboration agreements with significant international pharmaceutical companies and research centers that have the ability and intent to conduct in vivo testing in animals. These confidential relationships will be disclosed within the protected portion of this proposal only.