ANTIBODIES TO HUMAN PANCREATIC TRYPSIN AND TRYPSINOGEN
ANTIBODIES TO HUMAN PANCREATIC TRYPSIN AND TRYPSINOGEN
人胰腺胰蛋白酶和胰蛋白酶原抗体
批准号：
3495721
负责人：
VIRGINIA B PATEL
金额：
$5.0万
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
项目状态：
已结题
起止时间：
1988-09-30 至 1989-07-31
关键词：
amylases antibody antibody specificity antigens chymotrypsin diagnosis design /evaluation enzyme linked immunosorbent assay human tissue hybridomas immunization immunological substance laboratory mouse laboratory rabbit monoclonal antibody pancreas enzyme pancreatitis peptidases postmortem triacylglycerol lipase trypsinogen zymogens
中文摘要
翻译
这一建议涉及制定程序
英文摘要
This proposal involves the development of procedures for the
purification of human pancreatic enzymes and zymogens and for the
development of polyclonal and monoclonal antibodies.
Specifically, the aims of this proposal are to prepare human
cationic trypsinogen, cationic trypsin, chymotrypsinogen I,
chymotrypsin 1, lipase, and amylase, and to use these as sources
of antigens for the production of both polyclonal and monoclonal
antibodies. These antibodies will then be utilized in Phase II to
develop ELISA assays for their measurement in serum and other
fluids. Both the pancreatic proteins, their polyclonal and
monoclonal antibodies, and the ELISA assays should be useful for
the commercial development of assay kits to measure pancreatic
abnormalities though the detection of pancreatic proteins in serum.
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