MODULAR DETECTOR SYSTEMS FOR MULTI-SLICE SPECT IMAGING

该项目的重要性涉及到需要一个高 分辨率SPECT（单光子发射计算机断层扫描）成像 系统进行功能性脑成像在两个学术中心和 医院的对于许多疾病，涉及脑内干扰的过程 功能协调发展的SPECT成像已被证明可以提供诊断信息 这与从PET（正电子发射断层扫描）获得的结果相似 研究，但其他解剖学方向的研究无法获得 成像技术，如CT和MRI。PET技术似乎是 主要停留在主要的医疗中心，而SPECT是更多的 广泛应用于临床的非侵入性功能成像技术。 长期目标是开发一种新型SPECT扫描仪， 满足商业和临床对高性能大脑的需求 以具有成本效益的方式用新的放射性药物进行成像。的 第一阶段建议的具体目标集中在发展 多晶体探测器模块。提出了两个不同的模块。 初步的模拟研究已经显示出有希望的结果。详细 定义了评估以下技术优点和可行性的程序： 这种模块化的方法，以补充圆柱形SPECT的设计， 我们实验室正在开发的系统。 专用高性能脑SPECT的商业市场 扫描仪正在蓬勃发展，并承诺将非常可观。我们的乐观 预测的终端系统的商业可行性的前景是基于 准直器的高分辨率和圆柱形的低成本 探测器系统该系统的预期灵敏度是 设计的传统单头旋转摄像机SPECT系统 对于相同的空间分辨率规格。

The significance of this project relates to the need for a high resolution SPECT (Single Photon Emission Computed Tomography) imaging system to perform functional brain imaging in both academic centers and hospitals. For many disease, processes involving disturbances in brain functions. SPECT imaging has been shown to provide diagnostic information which is similar to that obtained from PET (Positron Emission Tomography) studies but which is not available from other anatomically oriented imaging techniques such as CT and MRI. It seems that PET technology is staying mainly in major medical centers, while SPECT is to be the more wide-spread clinical technique for non-invasive functional imaging. The long term objective is to develop a new type of SPECT scanner to fulfill the commercial and clinical need for high performance brain imaging with the new radiopharmaceuticals in a cost-effective manner. The specific aims in the Phase I proposal are focused on the development of multi-crystal detector modules. Two different modules are proposed. Preliminary simulation studies have shown promising results. Detailed procedures are defined to evaluate the technical merit and feasibility of this modular approach to complement the design of a cylindrical SPECT system being developed in our lab. The commercial market for a dedicated high performance brain SPECT scanner is booming and promises to be very substantial. Our optimistic outlook of the commercial viability of the projected end system is based on the high resolution of the collimator and low cost of the cylindrical detector system. The expected sensitivity of the system is 4 times of that of a conventional single head rotating camera SPECT system designed for the same spatial resolution specifications.