TRANSIENT GAS SENSORS

传统的克拉克型氧传感器需要频繁的重新校准。 体内植入时由于膜污染，电解液厚度 由于压力变化而发生的变化，以及流体流量的波动 血。提出了一种改进的氧传感器(即改进的Clark 传感器)，减少或消除了许多这样的问题。这个 所提出的传感器使用以下方法：1)测量脉冲 基于瞬时扩散浓度的建立 梯度，2)用于原位条件反射的电波形 (重新激活)传感器电极，3)所有贵金属，非- 在无氯、酸性电解液中污染电极，以及4) 提高信噪比的传感电极几何形状。 在第一阶段，最佳材料和电气参数将是 选择完全基于体外实验室测试的 宏传感器。第二阶段的工作将集中在翻译以下内容 技术应用于植入式血液和/或组织氧气传感器 测量和实施广泛的活体测试计划 目的是验证该方法，并对传感器进行优化。

The conventional Clark type oxygen sensor needs frequent recalibration when implanted in vivo due to membrane fouling, electrolyte thickness changes due to pressure variations, and the fluctuating flow rate of blood. An improved oxygen sensor is proposed (which is a modified Clark sensor) which reduces or eliminates many of those problems. The proposed sensor uses the following approaches: 1) a measuring pulse based on the establishment of a transient diffusional concentration gradient, 2) an electrical waveform for in situ conditioning (reactivating) of the sensor electrode, 3) all noble metal, non- contaminating electrodes in a non-chloride, acidic electrolyte, and 4) sensing electrode geometries which enhance the signal to noise ratio. During Phase I the optimum material and electrical parameters will be chosen based exclusively on in vitro laboratory testing of a macrosensor. Work during Phase II will concentrate on translating this technology into an implantable sensor for blood and/or tissue oxygen measurements and on carrying out an extensive in vivo testing program aimed at verifying the approach and at optimization of the sensor.