ULTRASENSITIVE NICKEL DETERMINATIONS FOR TOXICOLOGY

越来越严格的要求对 食品中有毒元素的检测与准确表征 环境健康。元素镍和镍的毒理学 金属有机形态，一直是人们关注的主题 最近几年。镍已经牵涉到许多 致癌、诱变、代谢和流行病学研究。 随着对生物机制的知识的扩展，人们希望 描述镍和其他金属在初期和初期的作用 微观水平也相应增加。最近的事态发展 共振电离光谱预示着量子飞跃 对痕量金属的敏感性。的选择性和敏感性 共振电离表明少数几种的绝对灵敏度 镍可以达到几千个原子，并伴随着好处 减少了样品制备、同位素稀释可靠性和 多元素势能。具体目标是：调查 镍的共振电离方案；开发简化的 生物基质中镍的分离方法研究 镍的雾化方法；并展示了超灵敏 镍分析。在第二阶段，方法论基础将是 扩展到其他有毒元素和一项合作研究 为将技术融入科学研究而建立的计划 社区。该技术的商业潜力预计将在 区域实验室的分析服务，以及 仪器设备的传播。

Increasingly stringent requirements are being placed on the detection and accurate characterization of toxic elements in environmental health. The toxicology of nickel, in elemental and metallo-organic form, has been the subject of much attention in recent years. Nickel has been implicated in numerous carcinogenetic, mutagenetic, metabolic and epidemiological studies. As the knowledge of biological mechanisms expands, the desire to characterize the role of nickel and other metals at incipient and microscopic levels increases accordingly. Recent developments in resonance ionization spectroscopy portend a quantum leap in sensitivity for trace metals. The selectivity and sensitivity of resonance ionization suggest that absolute sensitivities of a few thousand atoms may be achieved for nickel, with attendant benefits of reduced sample preparation, isotope dilution reliability and multielement potential. The specific aims are to: investigate resonance ionization schemes for nickel; develop simplified separation methods for nickel in biological matrices: investigate atomization methods for nickel; and demonstrate ultrasensitive nickel analyses. In Phase II the methodology base would be extended to other toxic elements and a collaborative research program established to integrate the technology into the scientific community. Commercial potential of the technology is expected for analytical services in regional laboratories, and in the dissemination of instrumentation.