Clonal haematopoiesis of indeterminate potential (CHIP) and its consequences for blood cancers, cardiovascular disease and stroke – the ASPREE-CHIP sub-study

通常与白血病等血癌相关的获得性基因突变可以在任何疾病出现之前很久就在血液或骨髓中检测到。被称为CHIP（潜力不确定克隆造血），它在老年人中更常见，并且与老年人常见的其他健康问题有关，如心脏病和中风。我们将在一项大型临床试验中研究CHIP的常见程度及其对健康的影响，试验对象为70岁或以上的健康人群。

Acquired genetic mutations normally associated with blood cancers like leukaemia can be detected in the blood or bone marrow long before any disease appears. Known as CHIP (clonal haematopoiesis of indeterminate potential), it is more common in older age, and has been associated with other health problems common in the elderly, like heart disease and stroke. We will study how common CHIP is, and its health consequences, in a large clinical trial of otherwise healthy people aged 70 or older.