PRODUCTION OF REFERENCE REAGENTS FOR SAIDS AND STLV-III

非人灵长类动物中两种不同的病毒诱导感染 其引起相当大的发病率和死亡率， 与人类艾滋病的相关性最近已被确定。 的 第一，指定SAIDS，是由各种密切相关的 D型病毒（SRV-1、SRV-2）。 第二种是由一个 慢病毒在形态学、生物学和血清学上 与人HTLV-III（HIV-1）和HTLV-IV（HIV-2）相关， 命名为STLV-III（SIV）。 这些感染很重要 因为它们：（a）感染许多非人类灵长类动物， 对这些物种中的实验的主要影响，以及（B）可以 作为研究生物学、发病机制 和潜在的艾滋病样疾病的治疗。 微生物学协会(MBA)建议生产 针对一系列表位的单克隆抗体， 猿类逆转录病毒 这些单克隆沿着多克隆 I期研究中产生的抗体将用于开发 SAIDS的简单、快速的抗体和抗原检测试验， SIV

Two distinct virally induced infections in non-human primates which cause substantial morbidity and mortality and with clinical relevance to human AIDS have been identified recently. The first, designated SAIDS, is caused by a variety of closely related Type D viruses (SRV-1, SRV-2). The second is induced by a lentivirus which is morphologically, biologically and serologically related to human HTLV-III (HIV-1) and HTLV-IV (HIV-2) and is designated STLV-III (SIV). These infections are of importance because they: (a) infect many non-human primates and may have major effects on experimentation in these species and (b) can serve as potential models for examining the biology, pathogenesis and potential therapy of AIDS-like diseases. Microbiological Associates, Inc. (MBA) proposes to produce monoclonal antibodies against a series of epitopes found on the simian retroviruses. These monoclonals along with polyclonal antibodies produced in Phase I studies will be used to develop simple, rapid antibody and antigen detection assays for SAIDS and SIV.