IMPLANTED SUB-MINIATURE LEFT VENTRICULAR ASSIST DEVICE

本研究的最终目标是研制一种亚微型电动机 驱动轴流泵，1）不会对血液造成不适当的损害，2） 将完全植入，允许胸腔闭合，以及3）将 心脏支持长达96小时。 第一阶段工作的目的是证明使用 直接放置在血流中的超微型泵， 慢性非搏动模式作为短期左心室辅助装置。 现有的泵设计将部分修改， 材料. 该泵将在三个体内测试中使用活体 狗 这些测试主要是为了检测任何血液损伤造成的 通过泵的存在和作用，并揭示血液 可能会对泵的运行产生影响。 替代泵材料和涂层将 选择并测试以寻求兼容性。 现有的泵具有更少的部件，比现有的泵小得多， 其他心脏辅助和人工心脏装置。 较小的设备 允许容易插入，并有助于关闭胸部， 改善患者舒适度并降低感染风险。

The ultimate objective of the research is to develop a sub-minature motor driven axial flow pump that 1) won't cause undue damage to the blood, 2) will be fully implantable allowing the chest to be closed, and 3) will provide cardiac support for up to 96 hours. The purpose of this Phase I effort is to prove the feasibility of using a sub-miniature pump placed directly in the blood stream to pump blood in a chronic nonpulsatile mode as a short term left ventricular assist device. An existing pump design will be modified in part with thrombo-resistant materials. The pump will be tested in three in-vivo tests using living dogs. The tests are primarily intended to detect any blood damage caused by the presence and action of the pump and to reveal any effects the blood might have upon pump operation. Alternate pump materials and coatings will be selected and tested in search of compatibility. The existing pump has fewer parts, is much smaller and much simpler than other cardiac assist and artificial heart devices. The smaller device allows ease of insertion and lends itself to closure of the chest, leading to improved patient comfort and a lower risk of infection.