EXTRA-CORPOREAL MEMBRANE ARTIFICIAL LUNG

这一计划的长期目标是开发一种改进的 用于长期体外气体交换的膜式人工肺系统 对婴儿和成人的支持。主要的设计目标是：1)优化 利用血膜二次流的气体交换效率 界面，从而将气体交换的表面积要求降至最低； 2)减少原始体积，使用新的可降低血液的聚合物表面 创伤和血栓形成，从而减少肝素化；以及3) 为膜提供有限的吸力和自泵能力 肺，消除了对重力供给式膀胱/滚柱泵组件的需要 并进一步减少引爆量。第一阶段的具体目标 该项目正在测试一种高效自泵的可行性 通过开发一台台式原型来执行一系列测试 目的是评价气体传递增强的程度和自身 系统的泵浦特性。最小接触区域 在血液和膜表面之间，减少了引爆量，以及 避免在这个新的膜肺中出现停滞点 随着使用改进的肝素涂层的微孔膜，有望 从而最大限度地减少对血小板的损伤，以及对血液的需求 肝素化是ECMO术中出血并发症的主要原因。

The long term objectives of this program are to develop an improved membrane artificial lung system for long term extra corporeal gas exchange support of infants and adults. The major design goals are: 1) to optimize gas exchange efficiency using secondary flows at the blood-membrane interface, thus minimizing the surface area requirements for gas exchange; 2) to reduce prime volume and use new polymeric surfaces which reduce blood trauma and thrombosis, thus allowing reduced heparinization; and 3) to provide a limited suction level and self-pumping capability to the membrane lung, eliminating the need for the gravity-fed bladder/roller pump assembly and to further reduce priming volume. The specific aims of the Phase I project are to test the feasibility of a high-efficiency self-pumping membrane lung by developing a bench prototype to perform a series of tests aimed at assessing the degree of gas transfer enhancement and the self- pumping characteristics of the system. The minimal contacting region between blood and membrane surfaces, the reduced priming volume, and the avoidance of stagnation points in this new membrane lung, in combination with the use of improved heparin coated microporous membranes, are expected to result in minimizing platelet injury, and the requirements for blood heparinization, the major causes of hemorrhagic complications during ECMO.