PULMONARY PEAK FLOW MONITOR AND RECORDER

这个应用程序建议完成一种监控方法的开发 并记录哮喘患者的肺功能及其他肺功能 病人。第一阶段的原型成功地展示了 这类装置的可行性。该装置测量的是肺峰值 流。它可以在LCD屏幕上即时显示结果。这个 这种设备的独特能力是它能够记录实际的 测量的峰值流量以及每次测量的日期和时间 四个月的时间。这份完整的肺部状态记录 然后可以通过患者的医生检索跨时间来帮助 临床决策。 该提案的第一阶段是一项可行性研究。在第二阶段 Forefront的具体目标是：1.完成高峰流量的设计 完成了解释器的设计与实现 从峰值流量设备检索数据并显示数据的软件 分析，3.设计和建造200个单元以供研究，4.验证 这些单元的性能通过内部测试，最重要的是， 5.通过一项双中心研究验证其临床意义 200个单位。 这种设备将对感兴趣的医生有重要的应用 在跟踪患者跨时间的峰值流量测量时 需要病人每天保存记录。另外，这个设备 可作为一种临床和研究工具用于研究 家庭环境中的支气管扩张剂功效。希望是，它可能是 用于改善哮喘的治疗。

This application proposes to finish development of a method of monitoring and recording the pulmonary function of asthmatic and other pulmonary patients. Prototypes in Phase I successfully demonstrated the feasibility of such devices. The device measures the pulmonary peak flow. It displays the results instantaneously on an LCD screen. The unique capacity of this device is its ability to record the actual measured peak flow together with the date and time of each measurement over a four month period. This complete record of pulmonary status across time can then by retrieved by the patient's physician to aid in clinical decision-making. Phase I of this proposal was a feasibility study. In Phase II Forefront's specific aims to: 1. Complete the design of the Peak Flow device, 2. Complete the design and implentation of the interpreter software which retrieves data from the Peak Flow device and presents data analysis, 3. Design and build 200 units for study, 4. Validate the performance of these units with internal testing, and most importantly, 5. Validate the clinical significance with a two center study using the 200 units. This device will have significant applications for physicians interested in tracking patients' peak flow measurements across time without requiring daily record keeping by patients. In addition, this device could be used as both a clinical and a research tool in the study of bronchodilator efficacy in home settings. The hope is that it may be utilized to improve the treatment of asthma.