Cloud-ready analysis methods and software to study effects of DNA variants on single-cell gene expression

研究DNA变异在单细胞中的作用将促进我们对健康和疾病细胞状态的理解。我们将开发统计方法来研究DNA变异对个体细胞中基因表达的影响，无论是在大量的人身上，还是在个体内的癌细胞群体中。单细胞分析需要大量的计算资源，因此我们将生产出可供集群和云计算平台上的所有研究人员轻松使用的软件。

Studying the effects of DNA variants in single cells will advance our understanding of healthy and diseased cell states. We will develop statistical methods to study the effects of DNA variants on gene expression in individual cells, both across large numbers of people and in cancerous cell populations within an individual. Single-cell analyses require large computational resources so we will produce software that can be used easily by all researchers on cluster and cloud computing platforms.