MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

该提案要求部分支持400 MHz高分辨率 核磁共振波谱仪。医院和核磁共振计划将 为该文书提供额外资金和长期支持。 作为MGH核磁共振计划的一部分，该光谱仪将成为 MGH由PHS支持的生物医学研究人员社区，由 研究司概述的内部咨询委员会 计划公告中的资源。 MGH核磁共振计划的范围，主要由小灵通资助 赠款，已扩大到包括体内光谱学以及 对化学结构的复杂研究。因此，这些实验 需要目前还不存在的高分辨率设备 MGH。具有项目所需某些能力的仪器 在此描述的信息偶尔可在邻近的 机构，但没有足够的时间，而且通常缺乏这样的 支持作为动物护理设施的功能。 该仪器将支持的一组生物医学研究项目是 可能是接受常规小灵通服务的范围最广的网站之一 资金问题。项目包括：实验性白内障的代谢研究 形成；调节脑细胞内pH的离子机制和高 能量磷酸盐；用作核磁共振成像造影剂的金属络合物；质子 组织中乳酸的光谱和化学位移成像；质子， 灌流心脏和活体心脏的碳、磷和钠光谱 使用外科植入线圈的心脏.新型高速光谱分析 分析算法以改进二维光谱和 光谱成像.高分辨率固态光谱学和 骨和合成生物材料的光谱成像和测量 蛋白质和合成肽的溶液构象和遗传 基因工程蛋白质。预计科学研究的水平 小灵通支持的研究人员的活动将显著增强 这台仪器在MGH的出现。

This proposal requests partial support for a 400 MHz high resolution nuclear magnetic resonance spectrometer. The hospital and NMR program will provide the additional funding and long-term support for this instrument. As part of the MGH NMR program, the spectrometer will be a resource to a community of PHS-supported biomedical researchers at the MGH and managed by the Internal Advisory Committee as outlined by the Division of Research Resources in the program announcement. The scope of the MGH NMR program, which is largely funded through PHS grants, has expanded to include in-vivo spectroscopy as well as sophisticated studies of chemical structure. Accordingly these experiments require high resolution equipment that does not presently exist at the MGH. Instruments with some of the capabilities required for the projects described herein are occasionally made available at neighboring institutions, but not for sufficient periods of time, and usually lack such support features as animal care facilities. The group of biomedical research projects this instrument will support is probably among the most wide ranging of sites receiving regular PHS funding. Projects include: metabolic studies of experimental cataract formation; ionic mechanisms regulating brain intracellular pH and high energy phosphates; metal chelates as NMR imaging contrast agents; proton spectroscopy and chemical shift imaging of lactate in tissue; proton, carbon, phosphorus and sodium spectroscopy of perfused hearts, and in-vivo hearts, using surgically implanted coils; novel high speed spectral analysis algorithms to to improve two-dimensional spectroscopy and spectroscopic imaging; high resolution solid state spectroscopy and spectroscopic imaging of bone and synthetic biomaterials; and measurement of solution conformation of proteins and synthetic peptides and genetically engineered proteins. It is anticipated that the level of scientific activities of PHS-supported researchers will be significantly enhanced by the presence of this instrument at the MGH.