RESEARCH METHODS FOR PREPROFESSIONAL STUDENTS

MBRS计划为教师和学生提供了独特的机会， 进行高质量的研究，这将是非常困难的，在这样一个 小型本科院校。 建议的工作分为六个部分 项目将涉及十四名学生每年，并将利用 教师的专业知识和夏洛特的定期顾问 纪念医院。 Drs. Chopra和Wright将研究4- 不同临床分离株和相似病原体分离的喹诺酮类药物 从不同的身体部位分离出来 博士罗素将利用各种吲哚合成方法， 吲哚稠合的4-喹诺酮类作为潜在的抗微生物剂， 用于NCI测试的所选褪黑激素类似物的制备， 潜在的细胞有丝分裂抑制剂 博士罗兹将分离和生化特性的纤连蛋白， 无脊椎动物 这些纤连蛋白也将被测试用于各种 生物活动。 博士萨顿-海伍德和李陶先生将研究 牛蛙 他们将分析脊索和它的矩阵， 利用光学和电子显微镜观察结构和功能变化， 酶分析和离子交换色谱法。 博士格林将调查身体和心理的压力， 面对老年人和影响适应的因素 过程 预测模型包括几个人口统计变量， 应对模式和社会支持。 博士Perumal将研究4-氧代羰基的红外吸收带， 喹诺酮类抗生素，并探讨其之间的关系 光谱数据和这些细菌的抗菌敏感性模式 针对不同细菌的抗生素。

The MBRS Program provides unique opportunities to faculty and students to conduct quality research which would have been very difficult at such a small undergraduate institution. The proposed work is subdivided into six projects which will involve fourteen students yearly and will utilize the expertise of faculty members and a regular consultant from Charlotte Memorial Hospital. Drs. Chopra and Wright will investigate the comparative effectiveness of 4- quinolones of different clinical isolates and similar pathogen isolated from different body sites in vitro. Dr. Russell will utilize various indole synthetic methods to prepare indole-fused 4-quinolones as potential antimicrobial agents and to complete the preparation of selected Melatonin analogs for testing by NCI as potential cell mitosis inhibitors. Dr. Rhodes will isolate and biochemically characterize fibronectin from invertebrates. These fibronectins will also be tested for various biological activities. Dr. Sutton-Haywood and Mr. Littau will study metamorphosis of tail portions of Rana catesbeiana. They will analyze the notochord and its matrix from structural and functional changes utilizing light and electron microscopy, enzyme analysis, and ion-exchange chromatography. Dr. Greene will investigate the physical and psychological stressors that confront older adults and the factors that influence the adaptation process. The predictive model includes several demographic variables, two coping models and social support. Dr. Perumal will study the 4-oxo carbonyl infrared absorption bands of 4- quinolone antibiotics and investigate the relationships between the spectral data and the antibacterial susceptibility patterns of these antibiotics against different bacteria.